3024279-60-2
3024279-60-2
Chemical Structure
CK1α degrader-3
- CAS No.: 3024279-60-2
- Formula:C22H19ClN4O4
- Molecular Weight:438.86
InChIKey: ZZKUJRVHLYOBRN-UHFFFAOYSA-N
SMILES: O=C(N1)CCC(N2CC3=C(C=CC(NC(N4CCC5=C4C=CC(Cl)=C5)=O)=C3)C2=O)C1=O
Biological Activity: CK1α degrader-3 (compound 197) is a casein kinase 1α (CK1α) molecular glue degrader. CK1α degrader-3 simultaneously binds and promotes the interaction between the CRBN E3 ubiquitin ligase and the target protein CK1α, thereby mediating the ubiquitination and proteasomal degradation of CK1α. CK1α degrader-3 can be used for research on various cancers[1].
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CK1α degrader-3 | CK1α degrader-3 (compound 197) is a casein kinase 1α (CK1α) molecular glue degrader. CK1α degrader-3 simultaneously binds and promotes the interaction between the CRBN E3 ubiquitin ligase and the target protein CK1α, thereby mediating the ubiquitination and proteasomal degradation of CK1α. CK1α degrader-3 can be used for research on various cancers. | |||||||||||||||||||||
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