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Cat. No.: HY-190252

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CK1α degrader-3

CK1α degrader-3 (compound 197) is a casein kinase 1α (CK1α) molecular glue degrader. CK1α degrader-3 simultaneously binds and promotes the interaction between the CRBN E3 ubiquitin ligase and the target protein CK1α, thereby mediating the ubiquitination and proteasomal degradation of CK1α. CK1α degrader-3 can be used for research on various cancers.

For research use only. We do not sell to patients.

CAS No.: 3024279-60-2
Formula: C₂₂H₁₉ClN₄O₄
Molecular Weight:438.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CK1α degrader-3 Chemical Structure

CAS No.: 3024279-60-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Description

IC₅₀ & Target

^[1]

CK1α

Cereblon

All Ligands for E3 Ligase Isoforms :

In Vitro

Molecular glue degraders are a class of small-molecule compounds that induce or stabilize non-native protein-protein interactions (PPIs) between target proteins and E3 ubiquitin ligases; by promoting the polyubiquitination of target proteins, they ultimately achieve specific degradation of disease-causing proteins in a manner dependent on the ubiquitin-proteasome system (UPS).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3024279-60-2
Molecular Weight 438.86
Formula C₂₂H₁₉ClN₄O₄
SMILES

O=C(N1)CCC(N2CC3=C(C=CC(NC(N4CCC5=C4C=CC(Cl)=C5)=O)=C3)C2=O)C1=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Laura Ann McAllister, et al. Molecular glue degraders and methods of using the same. WO2023244815A1. WIPO. 2023-12-21.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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- In Vitro
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CK1α degrader-3

All Ligands for E3 Ligase Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CK1α degrader-3 Related Classifications

HY-190252 Related Classifications

Bioz

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