3025467-27-7
3025467-27-7
Chemical Structure
WEE1 degrader-3
- CAS No.: 3025467-27-7
- Formula:C27H26N4O4
- Molecular Weight:470.52
InChIKey: RQUFDPMVFOMKBJ-XEGCMXMBSA-N
SMILES: O=C1N(C2C(NC(CC2)=O)=O)CC3=CC=C(O[C@@H]4CN(CC4)CC5=CC6=C(C=CC=C6)N=C5)C=C31
Biological Activity: WEE1 degrader-3 is a WEE1 molecular glue degrader. WEE1 degrader-3 recruits the E3 ubiquitin ligase Cereblon (CRBN) to WEE1, mediating WEE1 ubiquitination and subsequent proteasomal degradation. WEE1 degrader-3 degrades WEE1-ePL with an EC50 of 0.0087 μM. WEE1 degrader-3 can be used for research on WEE1-dependent tumors[1].
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WEE1 degrader-3 | WEE1 degrader-3 is a WEE1 molecular glue degrader. WEE1 degrader-3 recruits the E3 ubiquitin ligase Cereblon (CRBN) to WEE1, mediating WEE1 ubiquitination and subsequent proteasomal degradation. WEE1 degrader-3 degrades WEE1-ePL with an EC50 of 0.0087 μM. WEE1 degrader-3 can be used for research on WEE1-dependent tumors. | |||||||||||||||||||||
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