30334-69-1
Chemical Structure
Perfluorobutanesulfonamide
Synonym(s): FBSA
- CAS No.: 30334-69-1
- Formula:C4H2F9NO2S
- Molecular Weight:299.11
IUPAC Name: 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonamide
InChIKey: FUVKFLJWBHVMHX-UHFFFAOYSA-N
SMILES: O=S(N)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)=O
Biological Activity: Perfluorobutanesulfonamide (FBSA) is a per- and polyfluoroalkyl substance (PFAS) and bovine carbonic anhydrase inhibitor with an IC50 of 1.486 µM. Perfluorobutanesulfonamide can be found as a contaminant in wastewater. Perfluorobutanesulfonamide inhibits the reversible CO2 hydration reaction catalyzed by zinc metalloenzymes. Perfluorobutanesulfonamide bioaccumulates in earthworms, is lethal to earthworms, and impairs avoidance of light. Perfluorobutanesulfonamide exhibits developmental toxicity in zebrafish embryos. Perfluorobutanesulfonamide can be used in research related to PFAS environmental chemistry and ecotoxicology[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Perfluorobutanesulfonamide | 98.56% | Perfluorobutanesulfonamide (FBSA) is a per- and polyfluoroalkyl substance (PFAS) and bovine carbonic anhydrase inhibitor with an IC50 of 1.486 µM. Perfluorobutanesulfonamide can be found as a contaminant in wastewater. Perfluorobutanesulfonamide inhibits the reversible CO2 hydration reaction catalyzed by zinc metalloenzymes. Perfluorobutanesulfonamide bioaccumulates in earthworms, is lethal to earthworms, and impairs avoidance of light. Perfluorobutanesulfonamide exhibits developmental toxicity in zebrafish embryos. Perfluorobutanesulfonamide can be used in research related to PFAS environmental chemistry and ecotoxicology. | ||||||||||||||||||||
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References
- [1]. Chen YJ, et al. Emerging Perfluorobutane Sulfonamido Derivatives as a New Trend of Surfactants Used in the Semiconductor Industry. Environmental science & technology. 2024 Jan 23;58(3):1648-1658. [Content Brief]
- [2]. Groffen T, et al. Bioaccumulation and toxicity of perfluorobutane sulfonate (PFBS) and perfluorobutane sulfonamide (FBSA) in Eisenia fetida and Eisenia andrei. Ecotoxicology and environmental safety. 2025 Sep 01;302:118562.
- [3]. Benfodda Z, et al. Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase. European journal of medicinal chemistry. 2010 Mar;45(3):1225-9. [Content Brief]
- [4]. Rericha Y, et al. Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity. iScience. 2022 Feb 18;25(2):103789.
