3036889-54-7
3036889-54-7
Chemical Structure
DEL-I25
- CAS No.: 3036889-54-7
- Formula:C21H23N5O3
- Molecular Weight:393.44
InChIKey: QJHULIVSOFPRHV-UHFFFAOYSA-N
SMILES: O=C(N1CC(NC(CCC2=CC=C(N)C=N2)=O)C1)CN3C(C4=CC=CC=C4C3)=O
Biological Activity: DEL-I25 is a potent GPX4 activator. The Kd values of DEL-I25 for human GPX4WT and GPX4R152H are 110 μM and 2 μM, respectively. DEL-I25 protects cells from ferroptosis (ferroptosis). DEL-I25 can be used in research on skin photoaging and Sedaghatian-type spondylometaphyseal dysplasia[1][2].
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DEL-I25 | DEL-I25 is a potent GPX4 activator. The Kd values of DEL-I25 for human GPX4WT and GPX4R152H are 110 μM and 2 μM, respectively. DEL-I25 protects cells from ferroptosis (ferroptosis). DEL-I25 can be used in research on skin photoaging and Sedaghatian-type spondylometaphyseal dysplasia. | |||||||||||||||||||||
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References
- [1]. Liu H, et al. Selective Small-Molecule Activator of Patient-Derived GPX4 Variant. ACS chemical biology. 2025 May 16;20(5):1107-1122. [Content Brief]
- [2]. Guo X, et al. Hesperidin from Chenpi Ameliorates Skin Photoaging by Targeting HSPA1L to Stabilize GPX4 and Suppress Ferroptosis. Antioxidants (Basel, Switzerland). 2026 Apr 14;15(4):484. [Content Brief]
