DEL-I25
Based on 1 publication(s) in Google Scholar
DEL-I25 is a potent GPX4 activator. The Kd values of DEL-I25 for human GPX4WT and GPX4R152H are 110 μM and 2 μM, respectively. DEL-I25 protects cells from ferroptosis (ferroptosis). DEL-I25 can be used in research on skin photoaging and Sedaghatian-type spondylometaphyseal dysplasia.
For research use only. We do not sell to patients.
- CAS No.: 3036889-54-7
- Formula: C21H23N5O3
- Molecular Weight:393.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) DEL-I25
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Biological Activity
Description
IC50 & Target
[1]|
GPX4 110 μM (Kd) |
GPX4R152H 2 μM (Kd) |
In Vitro
DEL-I25 (48 h) selectively increases RAG03 lymphoblast viability and rescues them from ferroptosis, with an EC50 of 2 μM[1].
DEL-I25 (200 μM; 30 min) selectively increases and restores GPX4R152H enzymatic activity in lysates of Gpx4-knockout Pfa-1 mouse cells expressing human GPX4R152H[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3036889-54-7
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Molecular Weight 393.44
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Formula C21H23N5O3
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SMILES
O=C(N1CC(NC(CCC2=CC=C(N)C=N2)=O)C1)CN3C(C4=CC=CC=C4C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Antioxidants (Basel)
Hesperidin from Chenpi Ameliorates Skin Photoaging by Targeting HSPA1L to Stabilize GPX4 and Suppress Ferroptosis. [Abstract]2026 Apr 14;15(4):484. PMID: 42072126
Purity & Documentation
References
[1]. Liu H, et al. Selective Small-Molecule Activator of Patient-Derived GPX4 Variant. ACS chemical biology. 2025 May 16;20(5):1107-1122. [Content Brief]
[2]. Guo X, et al. Hesperidin from Chenpi Ameliorates Skin Photoaging by Targeting HSPA1L to Stabilize GPX4 and Suppress Ferroptosis. Antioxidants (Basel, Switzerland). 2026 Apr 14;15(4):484. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DEL-I25 Related Classifications
HY-172675 Related Classifications
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