3040858-60-1
3040858-60-1
Chemical Structure
CP-LC-0729
- CAS No.: 3040858-60-1
- Formula:C43H85N3O4S
- Molecular Weight:740.22
InChIKey: SLYPWRKMBWAIST-UHFFFAOYSA-N
SMILES: O=C(CCSCCC(C(NCCN(C)C)=O)NC(C(CCCCCCCC)CCCCCC)=O)OCC(CCCCCCCC)CCCCCC
Biological Activity: CP-LC-0729 is an ionizable lipid containing a thioester bond, used for mRNA/circRNA lipid nanoparticle (LNP) delivery. CP-LC-0729 possesses excellent endosomal escape capability and high biodegradability. mRNA lipid nanoparticles prepared with CP-LC-0729 exhibit lung-targeting properties. CP-LC-0729 has low cytotoxicity. CP-LC-0729 can be used for COVID-19 research[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CP-LC-0729 | 99.92% | CP-LC-0729 is an ionizable lipid containing a thioester bond, used for mRNA/circRNA lipid nanoparticle (LNP) delivery. CP-LC-0729 possesses excellent endosomal escape capability and high biodegradability. mRNA lipid nanoparticles prepared with CP-LC-0729 exhibit lung-targeting properties. CP-LC-0729 has low cytotoxicity. CP-LC-0729 can be used for COVID-19 research. | ||||||||||||||||||||
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References
- [1]. Mata E, et al. Preserved efficacy of lyophilized SARS-CoV-2 mRNA vaccine incorporating novel ionizable lipids after one year at 25 °C. NPJ vaccines. 2025 Jul 01;10(1):135.
- [2]. Giménez-Warren J, et al. STAAR Lipids: A Novel Ionizable Lipid Synthetic Platform for Efficient mRNA Delivery In Vivo with Tunable Lung Targeting.
- [3]. Mata E, et al. Enhanced stability and efficacy of a lyophilized mRNA SARS-CoV-2 vaccine incorporating novel Ionizable lipids after one year storage at 25ºC.
- [4]. Peña Á, et al. Thioester-Containing Ionizable Lipids with Enhanced Endosomal Escape and Biodegradability for mRNA and tRNA Delivery. Pharmaceutics. 2026 Apr 13;18(4):472.
- [5]. Broset E, et al. A Complete Approach for circRNA Therapeutics from Purification to Lyophilized Delivery Using Novel Ionizable Lipids. International journal of molecular sciences. 2025 May 27;26(11):5138.
- [6]. El-Sehrawy AAMA, et al. Circular Logic: Engineering Next-Generation Circular RNA Therapeutics for Precision Oncology. Biotechnology and bioengineering. 2026 Aug 12.
- [7]. Li X. Special Issue “Properties and Applications of Nanoparticles and Nanomaterials: ”. International journal of molecular sciences. 2025 Jul 15;26(14):6763.
