3045463-99-5
3045463-99-5
Chemical Structure
RBM39-IN-1
- CAS No.: 3045463-99-5
- Formula:C17H11N5O4S
- Molecular Weight:381.37
InChIKey: HYPXXPJXEKYGFU-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C2=NNC(O2)=O)C=C1)(NC3=CC=CC4=C3NC=C4C#N)=O
Biological Activity: RBM39-IN-1 is a sulfonamide-based RNA binding motif protein 39 (RBM39) molecular glue degrader that promotes the formation of a ternary complex between RBM39 and the CUL4-DCAF15 E3 ubiquitin ligase, inducing RBM39 polyubiquitination and proteasomal degradation. RBM39-IN-1 is used in research on RBM39-related tumors (including renal cell carcinoma and ovarian cancer)[1].
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RBM39-IN-1 | RBM39-IN-1 is a sulfonamide-based RNA binding motif protein 39 (RBM39) molecular glue degrader that promotes the formation of a ternary complex between RBM39 and the CUL4-DCAF15 E3 ubiquitin ligase, inducing RBM39 polyubiquitination and proteasomal degradation. RBM39-IN-1 is used in research on RBM39-related tumors (including renal cell carcinoma and ovarian cancer). | |||||||||||||||||||||
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