3065850-89-4
3065850-89-4
Chemical Structure
GSPT1 degrader-26
- CAS No.: 3065850-89-4
- Formula:C24H24N4O5
- Molecular Weight:448.47
InChIKey: HOGAYZZVBRZZLU-ZXVVBBHZSA-N
SMILES: O=C(NCC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2)=O)C=C1)/C(CC4=CC=CC=C4)=N/OC
Biological Activity: GSPT1 degrader-26 is a molecular glue degrader containing an oxime structure that recruits the E3 ligase cereblon (CRBN). GSPT1 degrader-26 exerts antiproliferative activity against acute myeloid leukemia (AML) cells by inducing ubiquitination and proteasomal degradation of G1 to S phase transition 1 protein (GSPT1). GSPT1 degrader-26 can be used for research on GSPT1-related tumors[1].
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GSPT1 degrader-26 | GSPT1 degrader-26 is a molecular glue degrader containing an oxime structure that recruits the E3 ligase cereblon (CRBN). GSPT1 degrader-26 exerts antiproliferative activity against acute myeloid leukemia (AML) cells by inducing ubiquitination and proteasomal degradation of G1 to S phase transition 1 protein (GSPT1). GSPT1 degrader-26 can be used for research on GSPT1-related tumors. | |||||||||||||||||||||
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