3072696-60-4
3072696-60-4
Chemical Structure
UNP-6457
- CAS No.: 3072696-60-4
- Formula:C62H71F3N14O10
- Molecular Weight:1229.31
InChIKey: ZAPBZKBLKRCOOA-DZWHKMBNSA-N
SMILES: O=C(C1=CC=CC=C1)N2[C@@]3([H])C[C@@](NC([C@@H](NC([C@H](CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CN4C=C(N=N4)C[C@@H](NC3=O)C(N)=O)=O)C(C)C)=O)CC5=CNC6=CC=CC=C56)=O)CC7=CC=CC=C7)=O)=O)C(C)C)=O)CC8=CC(C(F)(F)F)=CC=C8)=O)([H])C2
Biological Activity: UNP-6457 is a selective MDM2 inhibitor (MDM2 IC50 8.9 nM; MDM4 IC50 3.30 μM). UNP-6457 has no anticancer activity against breast cancer[1][2].
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UNP-6457 | UNP-6457 is a selective MDM2 inhibitor (MDM2 IC50 8.9 nM; MDM4 IC50 3.30 μM). UNP-6457 has no anticancer activity against breast cancer. | |||||||||||||||||||||
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References
- [1]. Silvestri AP, et al. DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2-p53 Inhibitor. ACS medicinal chemistry letters. 2023 Jun 08;14(6):820-826. [Content Brief]
- [2]. Li B, et al. Macrocyclic Peptides Containing an Imidazopyridinium (IP) Unit Display Enhanced Passive Cell Permeability. Journal of the American Chemical Society. 2026 Apr 08;148(13):13581-13591.
