3074816-62-6
3074816-62-6
Chemical Structure
DS21150768
- CAS No.: 3074816-62-6
- Formula:C36H32F2N6O2
- Molecular Weight:618.68
InChIKey: UAUOPQIZEQRXRH-UHFFFAOYSA-N
SMILES: FC1=CC=C(N2C(C(C(NC3=CC=C(C4=C(N)N=CC(C5=CC(C)=NC(C)=C5)=C4)C=C3)=O)=C(NCC6(C7)CC7(F)C6)C=C2)=O)C=C1
Biological Activity: DS21150768 is an orally active HPK1 inhibitor with an IC50 of 3.27 nM against hHPK1. DS21150768 decreases pSLP76 levels and increases IL-2 levels. DS21150768 shows antitumor effects in multiple syngeneic mouse tumor models, and in combination with anti-PD-1 antibody enhances antitumor efficacy in multiple models. DS21150768 induces immune-related gene signatures in responsive tumor models[1].
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DS21150768 | 99.16% | DS21150768 is an orally active HPK1 inhibitor with an IC50 of 3.27 nM against hHPK1. DS21150768 decreases pSLP76 levels and increases IL-2 levels. DS21150768 shows antitumor effects in multiple syngeneic mouse tumor models, and in combination with anti-PD-1 antibody enhances antitumor efficacy in multiple models. DS21150768 induces immune-related gene signatures in responsive tumor models. | ||||||||||||||||||||
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