3076932-73-2
Chemical Structure
DDB1 ligand-4
- CAS No.: 3076932-73-2
- Formula:C18H15F4N5O
- Molecular Weight:393.34
InChIKey: KJEGNVGGHWUQBI-YMTOWFKASA-N
SMILES: C[C@H](C1=CN(C2=CC(F)=CC(F)=C2)N=C1)C(NC3=NNC([C@@H]4C(F)(F)C4)=C3)=O
Biological Activity: DDB1 ligand-4 (compound 24) is a molecular glue that acts as a DNA damage-binding protein 1 (DDB1) ligand. DDB1 ligand-4 induces conformational changes by binding to the active site of CDK12/13, stabilizing the interaction between CDK12/13:CCNK and the cullin-RING E3 ubiquitin ligase complex (DDB1:CUL4B) independently of a specific substrate receptor, thereby mediating the degradation of CCNK. DDB1 ligand-4 can be used for cancer research[1].
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DDB1 ligand-4 | DDB1 ligand-4 (compound 24) is a molecular glue that acts as a DNA damage-binding protein 1 (DDB1) ligand. DDB1 ligand-4 induces conformational changes by binding to the active site of CDK12/13, stabilizing the interaction between CDK12/13:CCNK and the cullin-RING E3 ubiquitin ligase complex (DDB1:CUL4B) independently of a specific substrate receptor, thereby mediating the degradation of CCNK. DDB1 ligand-4 can be used for cancer research. | |||||||||||||||||||||
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