DDB1 ligand-4
DDB1 ligand-4 (compound 24) is a molecular glue that acts as a DNA damage-binding protein 1 (DDB1) ligand. DDB1 ligand-4 induces conformational changes by binding to the active site of CDK12/13, stabilizing the interaction between CDK12/13:CCNK and the cullin-RING E3 ubiquitin ligase complex (DDB1:CUL4B) independently of a specific substrate receptor, thereby mediating the degradation of CCNK. DDB1 ligand-4 can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3076932-73-2
- Formula: C18H15F4N5O
- Molecular Weight:393.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Cereblon-DDB1 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3076932-73-2
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Molecular Weight 393.34
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Formula C18H15F4N5O
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SMILES
C[C@H](C1=CN(C2=CC(F)=CC(F)=C2)N=C1)C(NC3=NNC([C@@H]4C(F)(F)C4)=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DDB1 ligand-4 Related Classifications
HY-190237 Related Classifications
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