3076933-25-7
3076933-25-7
Chemical Structure
DDB1 ligand-3
- CAS No.: 3076933-25-7
- Formula:C19H20ClN5O2
- Molecular Weight:385.85
InChIKey: NUZGTCIAZZPITH-LLVKDONJSA-N
SMILES: C[C@H](C1=CN(C2=CC(OC)=CC(Cl)=C2)N=C1)C(NC3=NNC(C4CC4)=C3)=O
Biological Activity: DDB1 ligand-3 is a molecular glue compound. DDB1 ligand-3 binds the CDK12/13:CCNK complex and induces its interaction with the DDB1:CUL4B E3 ubiquitin ligase, thereby promoting CCNK ubiquitination and proteasomal degradation, and exhibits nanomolar-level antiproliferative activity in breast cancer cell lines[1].
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DDB1 ligand-3 | DDB1 ligand-3 is a molecular glue compound. DDB1 ligand-3 binds the CDK12/13:CCNK complex and induces its interaction with the DDB1:CUL4B E3 ubiquitin ligase, thereby promoting CCNK ubiquitination and proteasomal degradation, and exhibits nanomolar-level antiproliferative activity in breast cancer cell lines. | |||||||||||||||||||||
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