3078788-63-0
3078788-63-0
Chemical Structure
ND-L11A TFA
- CAS No.: 3078788-63-0
- Formula:C39H52F6N10O4
- Molecular Weight:838.89
InChIKey: XKEVBVQHFBQXIP-GKEJWYBXSA-N
SMILES: OC(C(F)(F)F)=O.NCCCCCCCCCCCNC(COC(C=C1C2=NC=C(N3C[C@@](N)(CCC3)CC(F)F)C(CN4C5=NC=NC(N)=C5N=C4)=C2)=C(C=C1)F)=O
Biological Activity: ND-L11A TFA is the R-configured enantiomer of the NSD2 degrader ND-L11, with KD >100 μM. ND-L11A TFA fails to induce significant NSD2 protein degradation in multiple myeloma KMS11 cells and shows no significant antiproliferative effect on NSD2-driven KMS11 cells. ND-L11A TFA can be used in the study of multiple myeloma[1].
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ND-L11A TFA | ND-L11A TFA is the R-configured enantiomer of the NSD2 degrader ND-L11, with KD >100 μM. ND-L11A TFA fails to induce significant NSD2 protein degradation in multiple myeloma KMS11 cells and shows no significant antiproliferative effect on NSD2-driven KMS11 cells. ND-L11A TFA can be used in the study of multiple myeloma. | |||||||||||||||||||||
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