3085023-09-9
Chemical Structure
METTL1-IN-1
- CAS No.: 3085023-09-9
- Formula:C21H21Cl2N5O3
- Molecular Weight:462.33
InChIKey: OOGXKSGMPYMQBZ-APPDUMDISA-N
SMILES: NC1=NC2=CN=CC(N3C[C@@H](OCC3)C(N4[C@H](C5=C(Cl)C=C(Cl)C=C5CC4)C)=O)=C2O1
Biological Activity: METTL1-IN-1 is an oxazolo[4,5-c]pyridine-dichlorodihydroisoquinoline hybrid derivative that inhibits METTL1-WDR4 methyltransferase (IC50 = 0.013 μM). METTL1-IN-1 downregulates the m7G methylation level of intracellular tRNA and inhibits tumor cell proliferation. METTL1-IN-1 can be used for research on METTL1-related diseases, such as cancer[1].
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METTL1-IN-1 | METTL1-IN-1 is an oxazolo[4,5-c]pyridine-dichlorodihydroisoquinoline hybrid derivative that inhibits METTL1-WDR4 methyltransferase (IC50 = 0.013 μM). METTL1-IN-1 downregulates the m7G methylation level of intracellular tRNA and inhibits tumor cell proliferation. METTL1-IN-1 can be used for research on METTL1-related diseases, such as cancer. | |||||||||||||||||||||
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