3105428-74-5
Chemical Structure
CSNK2-IN-1
- CAS No.: 3105428-74-5
- Formula:C22H25N11
- Molecular Weight:443.51
InChIKey: VVIQQTQLDDARAW-UHFFFAOYSA-N
SMILES: N#CC1=C2N=C(C=C(N2N=C1)NC3CC3)NC4=CC=C(C(N5C=NN=C5)=C4)N(CC)CCN
Biological Activity: CSNK2-IN-1 is a potent and selective CSNK2 inhibitor with IC50 of 1.7 nM and 0.66 nM for CSNK2A1 and CSNK2A2, respectively. CSNK2-IN-1 has antiviral activity against beta-coronaviruses such as SARS-CoV-2 and MHV. CSNK2-IN-1 has good solubility, metabolic stability, and low cytotoxicity, but its plasma concentration in vivo decreases rapidly and is insufficient to achieve pharmacological effects. CSNK2-IN-1 can be used in the research of antiviral drug development[1].
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CSNK2-IN-1 | CSNK2-IN-1 is a potent and selective CSNK2 inhibitor with IC50 of 1.7 nM and 0.66 nM for CSNK2A1 and CSNK2A2, respectively. CSNK2-IN-1 has antiviral activity against beta-coronaviruses such as SARS-CoV-2 and MHV. CSNK2-IN-1 has good solubility, metabolic stability, and low cytotoxicity, but its plasma concentration in vivo decreases rapidly and is insufficient to achieve pharmacological effects. CSNK2-IN-1 can be used in the research of antiviral drug development. | |||||||||||||||||||||
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