312769-66-7
Chemical Structure
cyclo-pAKKR
- CAS No.: 312769-66-7
- Formula:C26H48N10O5
- Molecular Weight:580.72
InChIKey: QFNKBJOQENURER-VYJAJWGXSA-N
SMILES: O=C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H]1CCCNC(N)=N)=O)=O)=O)[C@@H]2N(C1=O)CCC2
Biological Activity: cyclo-pAKKR is a mimetic of the BDNF-binding region of p75NTR and a p75NTR agonist. cyclo-pAKKR promotes peripheral neuron survival and peripheral nerve myelination. cyclo-pAKKR, through a p75NTR-dependent signaling pathway, alleviates demyelination and axonal pathological damage, improves motor function performance in the experimental autoimmune neuritis (EAN) model, whereas a control peptide with an altered spatial conformation of the KKR motif does not produce such biological effects. cyclo-pAKKR can be used for research related to autoimmune neuritis[1].
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cyclo-pAKKR | cyclo-pAKKR is a mimetic of the BDNF-binding region of p75NTR and a p75NTR agonist. cyclo-pAKKR promotes peripheral neuron survival and peripheral nerve myelination. cyclo-pAKKR, through a p75NTR-dependent signaling pathway, alleviates demyelination and axonal pathological damage, improves motor function performance in the experimental autoimmune neuritis (EAN) model, whereas a control peptide with an altered spatial conformation of the KKR motif does not produce such biological effects. cyclo-pAKKR can be used for research related to autoimmune neuritis. | |||||||||||||||||||||
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