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Cat. No.: HY-P12386

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cyclo-pAKKR

cyclo-pAKKR is a mimetic of the BDNF-binding region of p75^NTR and a p75^NTR agonist. cyclo-pAKKR promotes peripheral neuron survival and peripheral nerve myelination. cyclo-pAKKR, through a p75^NTR-dependent signaling pathway, alleviates demyelination and axonal pathological damage, improves motor function performance in the experimental autoimmune neuritis (EAN) model, whereas a control peptide with an altered spatial conformation of the KKR motif does not produce such biological effects. cyclo-pAKKR can be used for research related to autoimmune neuritis.

For research use only. We do not sell to patients.

CAS No.: 312769-66-7
Formula: C₂₆H₄₈N₁₀O₅
Molecular Weight:580.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

cyclo-pAKKR Chemical Structure

CAS No.: 312769-66-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
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Biological Activity

Description

In Vivo

cyclo-pAKKR (cyclo-DPAKKR) (0.1-10 mg/kg/d; daily intraperitoneal administration) ameliorates disease severity, delays onset, accelerates recovery, elevates myelin basic protein levels, reduces macrophage infiltration and axonal damage, and improves motor function in rodent EAN models, and this effect is abolished in p75^NTR heterozygous mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 312769-66-7
Molecular Weight 580.72
Formula C₂₆H₄₈N₁₀O₅
SMILES

O=C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H]1CCCNC(N)=N)=O)=O)=O)[C@@H]2N(C1=O)CCC2
Sequence

Cyclo(D-Pro-Ala-Lys-Lys-Arg)
Sequence Shortening

Cyclo(D-Pro-AKKR)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gonsalvez DG, et al. A Brain-Derived Neurotrophic Factor-Based p75 Peptide Mimetic Ameliorates Experimental Autoimmune Neuritis Induced Axonal Pathology and Demyelination. eNeuro. 2017;4(3):ENEURO.0142-17.2017.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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