3127776-54-6
Chemical Structure
nAChR-IN-3
- CAS No.: 3127776-54-6
- Formula:C18H14ClN5O3
- Molecular Weight:383.79
InChIKey: JXKGVJFFQKDXIS-UHFFFAOYSA-N
SMILES: ClC1=CC=C(CN2C=CC=C3C2=NC(N(C4=C(C)ON=C4C)C3=O)=O)C=N1
Biological Activity: nAChR-IN-3 is an nAChR α6 subunit inhibitor and broad-spectrum insecticide against Acyrthosiphon pisum, Nilaparvata lugens, and Bemisia tabaci. nAChR-IN-3 acts through the nicotinic acetylcholine receptor α6 subunit; α6 silencing increases aphid tolerance and α6-null Drosophila show high-level resistance. nAChR-IN-3 disrupts ionic homeostasis and cholinergic signaling in nerve cells. nAChR-IN-3 induces mitochondrial electron transport chain disruption and reactive oxygen species burst. nAChR-IN-3 inhibits ATP synthesis and collapses energy metabolism. nAChR-IN-3 shows low toxicity to non-target honeybees, zebrafish, and earthworms and no inhibition of crop seed germination or seedling development. nAChR-IN-3 displays cytotoxicity in human keratinocytes and renal cells[1].
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nAChR-IN-3 | nAChR-IN-3 is an nAChR α6 subunit inhibitor and broad-spectrum insecticide against Acyrthosiphon pisum, Nilaparvata lugens, and Bemisia tabaci. nAChR-IN-3 acts through the nicotinic acetylcholine receptor α6 subunit; α6 silencing increases aphid tolerance and α6-null Drosophila show high-level resistance. nAChR-IN-3 disrupts ionic homeostasis and cholinergic signaling in nerve cells. nAChR-IN-3 induces mitochondrial electron transport chain disruption and reactive oxygen species burst. nAChR-IN-3 inhibits ATP synthesis and collapses energy metabolism. nAChR-IN-3 shows low toxicity to non-target honeybees, zebrafish, and earthworms and no inhibition of crop seed germination or seedling development. nAChR-IN-3 displays cytotoxicity in human keratinocytes and renal cells. | |||||||||||||||||||||
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