nAChR-IN-3
nAChR-IN-3 is an nAChR α6 subunit inhibitor and broad-spectrum insecticide against Acyrthosiphon pisum, Nilaparvata lugens, and Bemisia tabaci. nAChR-IN-3 acts through the nicotinic acetylcholine receptor α6 subunit; α6 silencing increases aphid tolerance and α6-null Drosophila show high-level resistance. nAChR-IN-3 disrupts ionic homeostasis and cholinergic signaling in nerve cells. nAChR-IN-3 induces mitochondrial electron transport chain disruption and reactive oxygen species burst. nAChR-IN-3 inhibits ATP synthesis and collapses energy metabolism. nAChR-IN-3 shows low toxicity to non-target honeybees, zebrafish, and earthworms and no inhibition of crop seed germination or seedling development. nAChR-IN-3 displays cytotoxicity in human keratinocytes and renal cells.
For research use only. We do not sell to patients.
- CAS No.: 3127776-54-6
- Formula: C18H14ClN5O3
- Molecular Weight:383.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human HaCAT keratinocytes, HK2 kidney cells, LX2 liver cells, WPMY-1 prostate cells, and rat RHNC hippocampal neuron cells
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Concentration:2.5, 5, 10, 20 μM
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Incubation Time:48 h
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Result:Produced dose-dependent cytotoxicity in HaCAT, HK2, LX2, WPMY-1, and RHNC cells, with HaCAT viability decreasing from 0.83 to 0.71 across 2.5-10 μM and HK2 viability of 0.57 at 10 μM.
In Vivo
nAChR-IN-3 (0.390625-50 mg/L; artificial feeding; 48 h) exhibits broad-spectrum high insecticidal activity against B. tabaci populations, with LC50 values ranging from 0.99 to 9.60 mg/L[1].
nAChR-IN-3 (200 μL Q1 insecticidal solution; agar feeding; 48 h) produces a highly resistant phenotype in α6-silenced Acyrthosiphon pisum and over 690-fold resistance in α6-knockout Drosophila melanogaster mutants, confirming nAChR α6 as its key target of action[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3127776-54-6
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Molecular Weight 383.79
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Formula C18H14ClN5O3
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SMILES
ClC1=CC=C(CN2C=CC=C3C2=NC(N(C4=C(C)ON=C4C)C3=O)=O)C=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
nAChR-IN-3 Related Classifications
HY-189740 Related Classifications
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Keywords
- nAChR-IN-3
- 3127776-54-6
- Insecticide
- Reactive Oxygen Species (ROS)
- ATP synthesis
- Acyrthosiphon pisum
- Bemisia tabaci
- Drosophila
- Nilaparvata lugens
- cholinergic signaling
- ionic homeostasis
- mitochondrial electron transport chain
- nicotinic acetylcholine receptor α6 subunit
- reactive oxygen species
- Inhibitor
- inhibitor
- inhibit