31586-29-5
Chemical Structure
Polysuccinimide
- CAS No.: 31586-29-5
- Formula:N/A
- Molecular Weight:60000 (Average)
SMILES: CC1CC(N(C)C1=O)=O.[n]
Biological Activity: Polysuccinimide is a polyimide precursor. Polysuccinimide can hydrolyze to polyaspartic acid (PASP), which has good biocompatibility and low toxicity. PASP can chelate Ca2+ and iron ions, exerting effects of inhibiting vascular calcification and scavenging ROS. Polysuccinimide is commonly used for enzyme immobilization and as a carrier for hydrophobic payloads, and its composites can impart antibacterial or wound-healing-promoting functions. Polysuccinimide can be used in research on cancer and chronic kidney disease-related vascular calcification[1][2][3][4][5].
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Polysuccinimide | Polysuccinimide is a polyimide precursor. Polysuccinimide can hydrolyze to polyaspartic acid (PASP), which has good biocompatibility and low toxicity. PASP can chelate Ca2+ and iron ions, exerting effects of inhibiting vascular calcification and scavenging ROS. Polysuccinimide is commonly used for enzyme immobilization and as a carrier for hydrophobic payloads, and its composites can impart antibacterial or wound-healing-promoting functions. Polysuccinimide can be used in research on cancer and chronic kidney disease-related vascular calcification. | |||||||||||||||||||||
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References
- [1]. Velazco-De-La-Garza J, et al. Biological properties of novel polysuccinimide derivatives synthesized via quaternary ammonium grafting. European Polymer Journal. 2020 May 15;131:109705.
- [2]. Jalalvandi E, Shavandi A. Polysuccinimide and its derivatives: Degradable and water soluble polymers[J]. European Polymer Journal, 2018, 109: 43-54.
- [3]. Adelnia H, et al. A Bioactive Disintegrable Polymer Nanoparticle for Synergistic Vascular Anticalcification. ACS nano. 2023 Oct 10;17(19):18775-18791.
- [4]. Zhang W, et al. Core-shell magnetic nanocarriers: Fe3O4-hydroxyapatite/polysuccinimide hybrids for enhanced oral bioavailability of fluorouracil. International Journal of Nanomedicine. 2025 Dec 31:3671-95.
- [5]. Tóth K, et al. Characterization of Electrospun Polysuccinimide-Dopamine Conjugates and Effect on Cell Viability and Uptake. Macromolecular bioscience. 2023 Mar;23(3):e2200397.
