Polysuccinimide
Polysuccinimide is a polyimide precursor. Polysuccinimide can hydrolyze to polyaspartic acid (PASP), which has good biocompatibility and low toxicity. PASP can chelate Ca2+ and iron ions, exerting effects of inhibiting vascular calcification and scavenging ROS. Polysuccinimide is commonly used for enzyme immobilization and as a carrier for hydrophobic payloads, and its composites can impart antibacterial or wound-healing-promoting functions. Polysuccinimide can be used in research on cancer and chronic kidney disease-related vascular calcification.
For research use only. We do not sell to patients.
- CAS No.: 31586-29-5
- Molecular Weight:60000 (Average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Polysuccinimide (25-200 μg/mL; 24 h) increases the proliferation of HepG2 human hepatocellular carcinoma cells[1].
Polysuccinimide (25-200 μg/mL; 24 h) inhibits the proliferation of 4T1 mouse breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3 murine fibroblast cells
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Concentration:25, 50, 100, 200 μg/mL
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Incubation Time:24 h; MTT 4 h
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Result:3T3 cell proliferation was 100.38% at 25 μg/mL, 100.12% at 50 μg/mL, 95.03% at 100 μg/mL, and 89.36% at 200 μg/mL.
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Cell Line:HeLa human cervical adenocarcinoma cells
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Concentration:25, 50, 100, 200 μg/mL
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Incubation Time:24 h; MTT 4 h
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Result:HeLa cell proliferation was 91.45% at 25 μg/mL, 88.98% at 50 μg/mL, 83.95% at 100 μg/mL, and 78.56% at 200 μg/mL.
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Cell Line:HepG2 human hepatocellular carcinoma cells
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Concentration:25, 50, 100, 200 μg/mL
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Incubation Time:24 h; MTT 4 h
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Result:HepG2 cell proliferation was 132.79% at 25 μg/mL, 128.13% at 50 μg/mL, 120% at 100 μg/mL, and 91.16% at 200 μg/mL.
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Cell Line:4T1 murine breast cancer cells
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Concentration:25, 50, 100, 200 μg/mL
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Incubation Time:24 h; MTT 4 h
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Result:4T1 cell proliferation was 107% at 25 μg/mL, 105.18% at 50 μg/mL, 95.22% at 100 μg/mL, and 79.32% at 200 μg/mL.
Chemical Information
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CAS No. 31586-29-5
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Molecular Weight 60000 (Average)
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SMILES
CC1CC(N(C)C1=O)=O.[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polysuccinimide Related Classifications
HY-172383 Related Classifications
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Keywords
- Polysuccinimide
- 31586-29-5
- Biochemical Assay Reagents
- 4T1
- Escherichia coli
- HeLa
- HepG2
- MOVAS
- PDLSCs
- RAW264.7
- SH-SY5Y
- antiproliferative
- apoptosis
- breast cancer
- calcium chelation
- cervical cancer
- enzyme immobilization
- fibroblast
- hydrophobic cargo carriers
- iron chelation
- proliferation
- reactive oxygen species
- tumor cell survival
- vascular calcification
- Inhibitor
- inhibitor
- inhibit