31773-95-2
Chemical Structure
Oleuropein Aglycone
Synonym(s): 3,4-DHPEA-EA
- CAS No.: 31773-95-2
- Formula:C19H22O8
- Molecular Weight:378.37
IUPAC Name: methyl (2R,4S,E)-4-(2-(3,4-dihydroxyphenethoxy)-2-oxoethyl)-3-ethylidene-2-hydroxy-3,4-dihydro-2H-pyran-5-carboxylate
InChIKey: BIWKXNFEOZXNLX-BBHIFXBUSA-N
SMILES: O=C(OCCC1=CC=C(O)C(O)=C1)C[C@H]2/C([C@H](O)OC=C2C(OC)=O)=C\C
Biological Activity: Oleuropein Aglycone (3,4-DHPEA-EA) is a secoiridoid that exerts antioxidant, anti-inflammatory, and anti-apoptotic effects by promoting ERK/AMPK/eNOS phosphorylation and inhibiting JNK/p38 MAPK and inflammation-related signaling pathways. Oleuropein Aglycone is used in research on acute kidney injury induced by ischemia-reperfusion injury, pleurisy, osteoporosis, Alzheimer's disease, neurodegenerative diseases, and triple-negative breast cancer[1][2][3][4][5][6][7][8][9][10].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Oleuropein Aglycone | 98.46% | Oleuropein Aglycone (3,4-DHPEA-EA) is a secoiridoid that exerts antioxidant, anti-inflammatory, and anti-apoptotic effects by promoting ERK/AMPK/eNOS phosphorylation and inhibiting JNK/p38 MAPK and inflammation-related signaling pathways. Oleuropein Aglycone is used in research on acute kidney injury induced by ischemia-reperfusion injury, pleurisy, osteoporosis, Alzheimer's disease, neurodegenerative diseases, and triple-negative breast cancer. | ||||||||||||||||||||
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References
- [1]. Nasrallah H, et al. Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney. Life sciences. 2020 Aug 15;255:117833.
- [2]. Impellizzeri D, et al. The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy. Clinical nutrition (Edinburgh, Scotland). 2011 Aug;30(4):533-40.
- [3]. Giordani C, et al. Differential Impact of Olive Leaf Extract and Its Secoiridoid Components, Oleuropein Aglycone and Oleacin, on Adipogenic Differentiation and Proliferation of Bone Marrow Mesenchymal Stem Cells. Pharmaceuticals (Basel, Switzerland). 2026 Feb 25;19(3):353.
- [4]. Leri M, et al. Natural Compound from Olive Oil Inhibits S100A9 Amyloid Formation and Cytotoxicity: Implications for Preventing Alzheimer's Disease. ACS chemical neuroscience. 2021 Jun 02;12(11):1905-1918.
- [5]. Nardi M, et al. Hydroxytyrosol oleate: A promising neuroprotective nanocarrier delivery system of oleuropein and derivatives. International Journal of Pharmaceutics. 2023 Jan 25;631:122498.
- [6]. Charoenprasert S, et al. Factors influencing phenolic compounds in table olives (Olea europaea). Journal of agricultural and food chemistry. 2012 Jul 25;60(29):7081-95.
- [7]. Silvestrini A, et al. Anti-Inflammatory Effects of Olive Leaf Extract and Its Bioactive Compounds Oleacin and Oleuropein-Aglycone on Senescent Endothelial and Small Airway Epithelial Cells. Antioxidants (Basel, Switzerland). 2023 Jul 28;12(8):1509.
- [8]. Castiglioni B, et al. Antioxidant and Anti-Osteoclastogenic Potential of Olive Oil Dregs Extracts. Molecules. 2026 Sep 10;31(18):3178.
- [9]. Madelou NA, et al. Time-Dependent Multimechanistic Antitumor Effects of Olive Oil Phenolics in a Triple-Negative Breast Cancer Mouse Model. Nutrients. 2026 Aug 23;18(17):2756. [Content Brief]
- [10]. Nardi M, et al. Biomimetic synthesis and antioxidant evaluation of 3,4-DHPEA-EDA [2-(3,4-hydroxyphenyl) ethyl (3S,4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate]. Food chemistry. 2014 Nov 01;162:89-93.
