34812-73-2
Chemical Structure
Diethylcarbamazine N-oxide
Synonym(s): DEC N-oxide
- CAS No.: 34812-73-2
- Formula:C10H21N3O2
- Molecular Weight:215.29
IUPAC Name: 4-(diethylcarbamoyl)-1-methylpiperazine 1-oxide
InChIKey: KAJAFGMERLXELG-UHFFFAOYSA-N
SMILES: O=C(N1CC[N+](CC1)([O-])C)N(CC)CC
Biological Activity: Diethylcarbamazine N-oxide (DEC N-oxide) is the N-oxide metabolite of Diethylcarbamazine (HY-12642A). Diethylcarbamazine N-oxide is stable to extraction in alkalinized urine but with low efficiency, and can be converted to Diethylcarbamazine upon thermal decomposition or reduction by sulfur dioxide. Diethylcarbamazine N-oxide can be used for the study of Diethylcarbamazine metabolism[1][2].
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Diethylcarbamazine N-oxide | Diethylcarbamazine N-oxide (DEC N-oxide) is the N-oxide metabolite of Diethylcarbamazine (HY-12642A). Diethylcarbamazine N-oxide is stable to extraction in alkalinized urine but with low efficiency, and can be converted to Diethylcarbamazine upon thermal decomposition or reduction by sulfur dioxide. Diethylcarbamazine N-oxide can be used for the study of Diethylcarbamazine metabolism. | |||||||||||||||||||||
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References
- [1]. Edwards G, et al. Identification and quantification of diethylcarbamazine and diethylcarbamazine N-oxide in rat urine. Xenobiotica. 1981 Apr;11(4):281-4.
- [2]. Faulkner JK, et al. Dealkylation and N-oxidation in the metabolism of i-diethylcarbamyl-4-methylpiperazine in the rat. Xenobiotica. 1972 Jan;2(1):59-68.
