357441-99-7
357441-99-7
Chemical Structure
N.41
- CAS No.: 357441-99-7
- Formula:C15H14N2O2
- Molecular Weight:254.28
IUPAC Name: (E)-3-((4-hydroxyphenyl)amino)-1-(pyridin-3-yl)but-2-en-1-one
InChIKey: YJVDMNPGQGXXGJ-PKNBQFBNSA-N
SMILES: C/C(NC1=CC=C(O)C=C1)=C\C(C2=CC=CN=C2)=O
Biological Activity: N.41 is an antiviral agent. N.41 protects APOBEC3G (an antiviral factor) from HIV Vif protein-mediated degradation. N.41 inhibits the Vif-A3G interaction and increases cellular A3G levels and incorporation of A3G into virions, thereby attenuating virus infectivity in a Vif-dependent manner. N.41 inhibits HIV-1 viral replication in PBMCs (IC50: 8.4 μM)[1].
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N.41 | N.41 is an antiviral agent. N.41 protects APOBEC3G (an antiviral factor) from HIV Vif protein-mediated degradation. N.41 inhibits the Vif-A3G interaction and increases cellular A3G levels and incorporation of A3G into virions, thereby attenuating virus infectivity in a Vif-dependent manner. N.41 inhibits HIV-1 viral replication in PBMCs (IC50: 8.4 μM). | |||||||||||||||||||||
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