391977-03-0
Chemical Structure
Heliomicin
- CAS No.: 391977-03-0
- Formula:C201H297N61O64S6
- Molecular Weight:4784.27
SMILES: O=C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(NCC(N[C@@H](CO)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@H]2CC(N)=O)=O)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](C(C)C)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(NCC(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]7CC8=CNC9=CC=CC=C89)=O)NC2=O)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)NC7=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC%10=CC=C(C=C%10)O)C(N[C@@H](CCCCN)C(NCC(NCC(N[C@H]3CC%11=CNC=N%11)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Biological Activity: Heliomicin is an antifungal peptide that binds to fungus-specific glucosylceramide sphingolipids. Fungal membrane glucosylceramide is required for the activity and growth inhibitory effect of Heliomicin. Heliomicin has no antibacterial activity against Gram-positive and Gram-negative bacteria. Heliomicin can be used in research related to fungal infections[1][2][3][4][5].
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Heliomicin | Heliomicin is an antifungal peptide that binds to fungus-specific glucosylceramide sphingolipids. Fungal membrane glucosylceramide is required for the activity and growth inhibitory effect of Heliomicin. Heliomicin has no antibacterial activity against Gram-positive and Gram-negative bacteria. Heliomicin can be used in research related to fungal infections. | |||||||||||||||||||||
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References
- [1]. Thevissen K, et al. Therapeutic potential of antifungal plant and insect defensins. Drug discovery today. 2007 Nov;12(21-22):966-71.
- [2]. Thevissen K, et al. Defensins from insects and plants interact with fungal glucosylceramides. Journal of Biological Chemistry. 2004 Feb 6;279(6):3900-5.
- [3]. Lamberty M, et al. Insect Immunity: isolation from the lepidopteran heliothis virescensof a novel insect defensin with potent antifungal activity. Journal of Biological Chemistry. 1999 Apr 2;274(14):9320-6.
- [4]. Lamberty M, et al. Solution structures of the antifungal heliomicin and a selected variant with both antibacterial and antifungal activities. Biochemistry. 2001 Oct 09;40(40):11995-2003. [Content Brief]
- [5]. Perez-Rodriguez A, et al. Antimicrobial peptides with anti-Candida activity. International journal of molecular sciences. 2022 Aug 17;23(16):9264.
