39927-08-7
39927-08-7
Chemical Structure
HOOC-PEG2000-COOH
- CAS No.: 39927-08-7
- Formula:N/A
- Molecular Weight:2000 (Average)
SMILES: O=C(O)COCCOCC(O)=O.[n]
Biological Activity: HOOC-PEG2000-COOH is a dicarboxyl-terminated polyethylene glycol and calcium ion chelator. HOOC-PEG2000-COOH inhibits platelet aggregation and contraction while promoting fibrinolysis and blood clot dissolution. HOOC-PEG2000-COOH can serve as a coating for superparamagnetic iron oxide nanoparticles in nanovaccine formulations, and as a bifunctional linker in pH-sensitive conjugates for siRNA delivery liposomes. HOOC-PEG2000-COOH can be used in research on thrombosis and atherosclerosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HOOC-PEG2000-COOH | 99.91% | HOOC-PEG2000-COOH is a dicarboxyl-terminated polyethylene glycol and calcium ion chelator. HOOC-PEG2000-COOH inhibits platelet aggregation and contraction while promoting fibrinolysis and blood clot dissolution. HOOC-PEG2000-COOH can serve as a coating for superparamagnetic iron oxide nanoparticles in nanovaccine formulations, and as a bifunctional linker in pH-sensitive conjugates for siRNA delivery liposomes. HOOC-PEG2000-COOH can be used in research on thrombosis and atherosclerosis. | ||||||||||||||||||||
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HOOC-PEG5000-COOH | HOOC-PEG5000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG5000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification. | |||||||||||||||||||||
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Poly(ethylene glycol) bis(carboxymethyl) ether (MW 250) | Poly(ethylene glycol) bis(carboxymethyl) ether (MW 250) is an amine-reactive crosslinking agent. | |||||||||||||||||||||
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HOOC-PEG1000-COOH | HOOC-PEG1000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG1000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification. | |||||||||||||||||||||
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HOOC-PEG10000-COOH | 99.89% | HOOC-PEG10000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG10000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification. | ||||||||||||||||||||
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HOOC-PEG20000-COOH | 99.90% | HOOC-PEG20000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG20000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification. | ||||||||||||||||||||
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Poly(ethylene glycol) bis(carboxymethyl) ether (MW 600) | Poly(ethylene glycol) bis(carboxymethyl) ether (MW 600) is an amine-reactive crosslinking agent. | |||||||||||||||||||||
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HOOC-PEG40000-COOH | 99.91% | HOOC-PEG40000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG40000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification. | ||||||||||||||||||||
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HOOC-PEG3400-COOH | HOOC-PEG3400-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG3400-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification. | |||||||||||||||||||||
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References
- [1]. Bian Y, et al. Carboxyl PEGylation of magnetic nanoparticles as antithrombotic and thrombolytic agents by calcium binding. Journal of colloid and interface science. 2023 May 15;638:672-685. [Content Brief]
- [2]. Zhang L, et al. A nanovaccine for immune activation and prophylactic protection of atherosclerosis in mouse models. Nature communications. 2025 Mar 02;16(1):2111. [Content Brief]
- [3]. Zang X, et al. Anti-EphA10 antibody-conjugated pH-sensitive liposomes for specific intracellular delivery of siRNA. International journal of nanomedicine. 2016;11:3951-67.
