441785-25-7
441785-25-7
Chemical Structure
Besifovir
Synonym(s): LB80331
- CAS No.: 441785-25-7
- Formula:C10H14N5O4P
- Molecular Weight:299.22
IUPAC Name: ((1-((2-amino-9H-purin-9-yl)methyl)cyclopropoxy)methyl)phosphonic acid
InChIKey: KDNSSKPZBDNJDF-UHFFFAOYSA-N
SMILES: NC1=NC=C2N=CN(CC3(OCP(O)(O)=O)CC3)C2=N1
Biological Activity: Besifovir (LB80331), a parent agent converted by LB80380 (HY-19447A), further metabolizes to its active form, LB80317 (HY-106235). Besifovir is an orally active, novel antiviral agent against hepatitis B virus (HBV)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Besifovir | 98.0% | Besifovir (LB80331), a parent agent converted by LB80380 (HY-19447A), further metabolizes to its active form, LB80317 (HY-106235). Besifovir is an orally active, novel antiviral agent against hepatitis B virus (HBV). | ||||||||||||||||||||
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References
- [1]. Jung JA, et al. Pharmacokinetic comparison of the maleate and free base formulations of LB80380, a novel nucleotide analog, in healthy male volunteers. Int J Clin Pharmacol Ther. 2012 Sep;50(9):657-64. [Content Brief]
- [2]. Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83. [Content Brief]
