470695-03-5
Chemical Structure
PUMAi
- CAS No.: 470695-03-5
- Formula:C19H28Cl2N2O3
- Molecular Weight:403.34
IUPAC Name: 1-(4-(2-hydroxyethyl)piperazin-1-yl)-3-(naphthalen-2-yloxy)propan-2-ol hydrochloride
InChIKey: BYEYELUOZVKLDE-UHFFFAOYSA-N
SMILES: OCCN1CCN(CC(COC2=CC3=C(C=CC=C3)C=C2)O)CC1.Cl.Cl
Biological Activity: PUMAi is a PUMA inhibitor that disrupts the interaction between PUMA and BCL-xL. PUMAi inhibits apoptosis, caspase-3 activation, WNT/NOTCH pathway activation, and DNA damage. PUMAi protects intestinal tissues in mice, promotes the growth of colonoids, and reduces chemotherapy-induced weight loss, gastrointestinal damage, and lethality. PUMAi alleviates acetaminophen-induced liver injury and cytoplasmic translocation of HMGB1 in mice. PUMAi can be used in studies related to gastrointestinal injury, intestinal injury, and liver injury[1][2][3].
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PUMAi | PUMAi is a PUMA inhibitor that disrupts the interaction between PUMA and BCL-xL. PUMAi inhibits apoptosis, caspase-3 activation, WNT/NOTCH pathway activation, and DNA damage. PUMAi protects intestinal tissues in mice, promotes the growth of colonoids, and reduces chemotherapy-induced weight loss, gastrointestinal damage, and lethality. PUMAi alleviates acetaminophen-induced liver injury and cytoplasmic translocation of HMGB1 in mice. PUMAi can be used in studies related to gastrointestinal injury, intestinal injury, and liver injury. | |||||||||||||||||||||
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References
- [1]. Yu J, et al. Method of preventing or treating treatment-induced gastrointestinal injury: US20220125746A1. 2022-04-28.
- [2]. Li M, et al. The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases. Apoptosis : an international journal on programmed cell death. 2021 Jun;26(5-6):235-247. [Content Brief]
- [3]. Chen D, et al. p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology. 2019;69(5):2164-2179.
