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Cat. No.: HY-167182

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PUMAi

PUMAi is a PUMA inhibitor that disrupts the interaction between PUMA and BCL-xL. PUMAi inhibits apoptosis, caspase-3 activation, WNT/NOTCH pathway activation, and DNA damage. PUMAi protects intestinal tissues in mice, promotes the growth of colonoids, and reduces chemotherapy-induced weight loss, gastrointestinal damage, and lethality. PUMAi alleviates acetaminophen-induced liver injury and cytoplasmic translocation of HMGB1 in mice. PUMAi can be used in studies related to gastrointestinal injury, intestinal injury, and liver injury.

For research use only. We do not sell to patients.

CAS No.: 470695-03-5
Formula: C₁₉H₂₈Cl₂N₂O₃
Molecular Weight:403.34

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Please store the product under the recommended conditions in the Certificate of Analysis.

PUMAi Chemical Structure

CAS No.: 470695-03-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target

^[1]

Caspase 3

Bcl-xL

All Bcl-2 Family Isoforms :

All Caspase Isoforms :

In Vitro

ApoptosisOthers

Apoptosis

PUMAi (50 μM; 24 h) protects mouse colon organoids and human primary colon organoids from CPT-induced growth inhibition, apoptosis, and WNT/Notch pathway activation^[1].

Others

PUMAi (25 μM; 15 min) inhibits the protein-protein interaction between PUMA and BCL-xL in HEK293 cell lysates, without affecting the interaction between BIM and MCL-1^[1].
PUMAi effectively disrupts the interaction between PUMA and BCL-XL in cell-free biochemical assays^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancerInnate ImmunityApoptosisProtein/Amino Acid MetabolismOthers

Anti-cancer

Innate Immunity

PUMAi (10 mg/kg; i.p.; 2 hours before and 20 hours after each of 6 CPT-11 doses) protects tumor-bearing mice from CPT-11-induced gastrointestinal injury and weight loss without compromising tumor response to chemotherapy^[1].

Apoptosis

PUMAi (10 mg/kg; i.p.; 2 hours before CPT-11) reduces LGR5⁺ intestinal stem cell apoptosis, niche cell expansion, and DNA damage in mice treated with CPT-11^[1].

Apoptosis

Protein/Amino Acid Metabolism

PUMAi (10 mg/kg; i.p.; single dose) administered 2 hours after acetaminophen overdose significantly reduces acetaminophen-induced liver necrosis and injury in mice, as evidenced by reduced serum ALT/AST levels, necrotic liver area, TUNEL-positive cells, and HMGB1 cytoplasmic translocation^[3].

Others

PUMAi (10 mg/kg; i.p.; 2 hours before and 20 hours after each of 6 CPT-11 doses) prevents LGR5⁺ intestinal stem cell exhaustion and preserves niche integrity in mice treated with repeated doses of CPT-11^[1].
PUMAi (10 mg/kg; i.p.; 2 hours before each of 3 CPT-11 doses, plus 1 dose 20 hours after final CPT-11 dose) increases survival to 70% in mice with CPT-11-induced lethal gastrointestinal injury^[1].
PUMAi (10 mg/kg; i.p.; 30 minutes before irradiation, 30 minutes after irradiation, and daily for 4 subsequent days) improves survival in mice with radiation-induced gastrointestinal injury^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 470695-03-5
Molecular Weight 403.34
Formula C₁₉H₂₈Cl₂N₂O₃
SMILES

OCCN1CCN(CC(COC2=CC3=C(C=CC=C3)C=C2)O)CC1.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yu J, et al. Method of preventing or treating treatment-induced gastrointestinal injury: US20220125746A1. 2022-04-28.

[2]. Li M, et al. The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases. Apoptosis : an international journal on programmed cell death. 2021 Jun;26(5-6):235-247. [Content Brief]

[3]. Chen D, et al. p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology. 2019;69(5):2164-2179.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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PUMAi

All Bcl-2 Family Isoforms

All Caspase Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

In Vivo

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PUMAi Related Classifications

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