479-43-6
479-43-6
Chemical Structure
Canthin-6-one
- CAS No.: 479-43-6
- Formula:C14H8N2O
- Molecular Weight:220.23
IUPAC Name: 6H-indolo[3,2,1-de][1,5]naphthyridin-6-one
InChIKey: ZERVJPYNQLONEK-UHFFFAOYSA-N
SMILES: O=C1N2C3=C(N=CC=C3C4=C2C=CC=C4)C=C1
Biological Activity: Canthin-6-one is an indole alkaloid, displays antibacterial and anti-inflammatory activities[1][2].
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Canthin-6-one | 99.92% | Canthin-6-one is an indole alkaloid, displays antibacterial and anti-inflammatory activities. | ||||||||||||||||||||
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9-Methoxycanthin-6-one | 99.80% | 9-Methoxycanthin-6-one, a canthin-6-one alkaloid, is present in intact plant parts and in callus tissues of different explants. 9-Methoxycanthin-6-one shows anti-tumor activity, inhibits LPS-induced TNF-α and IL-1β. | ||||||||||||||||||||
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11-Hydroxycanthin-6-one | 11-Hydroxycanthin-6-one, a canthin-6-one (HY-N3536) alkaloid, is an antitumor agent which shows potent cytotoxic activity. | |||||||||||||||||||||
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Canthin-6-one N-oxide | Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity. | |||||||||||||||||||||
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10-Methoxy-canthin-6-one | 98.71% | 10-Methoxy-canthin-6-one (Mtx-C) is analkaloid derivative. 10-Methoxy-canthin-6-one can induce DNA damage by intercalating into DNA. 10-Methoxy-canthin-6-one can inhibit cancer cells proliferation, cause G2/M phase arrest and induce myeloid differentiation. T10-Methoxy-canthin-6-one can upregulate the expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 10-Methoxy-canthin-6-one also exhibits anti-bacterial activity. 10-Methoxy-canthin-6-one can be used for the researches of cancer and infection, such as acute myeloid leukemias (AML). | ||||||||||||||||||||
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4-Hydroxycanthin-6-one | 4-Hydroxycanthin-6-one is a novel quinoline alkaloid isolated from the stem bark of the tree Ailanthus altissima. Five other known compounds were also found in the study. The structures of the new compounds were determined by interpretation of physical and spectroscopic data, and their absolute configurations were determined by electronic circular dichroism spectroscopy and quantum chemical calculations. These compounds showed significant inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells, showing potential anti-inflammatory properties. | |||||||||||||||||||||
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1-Hydroxycanthin-6-one | 1-Hydroxycanthin-6-one is an alkaloid that can be found in Ailanthus giraldii. | |||||||||||||||||||||
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10-Hydroxycanthin-6-one | 10-Hydroxycanthin-6-one is an antileukemic canthin-6-one alkaloid from Brucea antidysenterica. Antitumor agent. | |||||||||||||||||||||
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9-Hydroxycanthin-6-one | 9-Hydroxycanthin-6-one is a β-carboline alkaloid. 9-Hydroxycanthin-6-one can be isolated from the roots of E. longifolia. 9-Hydroxycanthin-6-one inhibits TNF-α-induced activation of the NF-κB pathway. 9-Hydroxycanthin-6-one activates GSK3β independently of CK1α, drives phosphorylation and degradation of β-catenin, and inhibits the Wnt signaling pathway. 9-Hydroxycanthin-6-one exerts selective cytotoxicity against Wnt-dependent colon cancer cells. 9-Hydroxycanthin-6-one can be used in studies related to colon cancer. | |||||||||||||||||||||
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5-Hydroxycanthin-6-one | 5-Hydroxycanthin-6-one is an alkaloid that can be isolated from Simarouba amara. | |||||||||||||||||||||
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5-Methoxycanthin-6-one | 5-Methoxycanthin-6-one is an orally active inhibitor of Leishmania strains. 5-Methoxycanthin-6-one shows cytotoxicity with an IC50 of 5.44 μg/mL against Ailanthus altissima cells. | |||||||||||||||||||||
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References
- [1]. O'Donnell G, Gibbons S. Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum. Phytother Res. 2007;21(7):653-657. [Content Brief]
- [2]. Cho SK, et al., Anti-inflammatory Effects of Canthin-6-one Alkaloids from Ailanthus altissima. Planta Med. 2018 May;84(8):527-535. [Content Brief]
