509093-72-5
509093-72-5
Chemical Structure
IRAK4-IN-5
- CAS No.: 509093-72-5
- Formula:C27H25F3N4O
- Molecular Weight:478.51
IUPAC Name: N-(1-phenyl-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide
InChIKey: CLRGCYMGDBZQTB-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC(C(F)(F)F)=C1)NC2=NC3=C(N2C4=CC=CC=C4)C=CC(CN5CCCCC5)=C3
Biological Activity: IRAK4-IN-5 is an interleukin-1 receptor-associated kinase 4 (IRAK-4) inhibitor with a Ki value of 2.8 nM. IRAK4-IN-5 interacts with non-conserved residues of IRAK-4, thereby conferring selectivity over related kinases. IRAK4-IN-5 can be used in the research of inflammatory lesions (atherosclerosis, arthritis)[1].
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IRAK4-IN-5 | IRAK4-IN-5 is an interleukin-1 receptor-associated kinase 4 (IRAK-4) inhibitor with a Ki value of 2.8 nM. IRAK4-IN-5 interacts with non-conserved residues of IRAK-4, thereby conferring selectivity over related kinases. IRAK4-IN-5 can be used in the research of inflammatory lesions (atherosclerosis, arthritis). | |||||||||||||||||||||
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