IRAK4-IN-5
IRAK4-IN-5 is an interleukin-1 receptor-associated kinase 4 (IRAK-4) inhibitor with a Ki value of 2.8 nM. IRAK4-IN-5 interacts with non-conserved residues of IRAK-4, thereby conferring selectivity over related kinases. IRAK4-IN-5 can be used in the research of inflammatory lesions (atherosclerosis, arthritis).
For research use only. We do not sell to patients.
- CAS No.: 509093-72-5
- Formula: C27H25F3N4O
- Molecular Weight:478.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IRAK4 2.8 nM (Ki) |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | CL | T1/2 | AUC0-∞ |
|---|---|---|---|---|---|
| Rat[1] | 0.5 mg/kg | i.v. | 0.54 L/h/kg | 23.7 h | 1023 μM·h |
Chemical Information
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CAS No. 509093-72-5
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Molecular Weight 478.51
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Formula C27H25F3N4O
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SMILES
O=C(C1=CC=CC(C(F)(F)F)=C1)NC2=NC3=C(N2C4=CC=CC=C4)C=CC(CN5CCCCC5)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IRAK4-IN-5 Related Classifications
HY-122707 Related Classifications
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