526186-99-2
Chemical Structure
HS-MMP-SH
- CAS No.: 526186-99-2
- Formula:C70H108N26O23S2
- Molecular Weight:1745.90
InChIKey: VOGQKNIWCIOYRG-PTOIZHEWSA-N
SMILES: O=C(NCC(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(NCC(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
Biological Activity: HS-MMP-SH is a bis-cysteine matrix metalloproteinase (MMP)-degradable peptide crosslinker that enables cell-mediated degradation of hyaluronic acid hydrogels. HS-MMP-SH undergoes Michael-type addition with acrylate-functionalized hyaluronic acid to form hydrogels. HA-MMP hydrogels crosslinked by HS-MMP-SH support cell infiltration and vascular invasion in vivo[1].
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HS-MMP-SH | HS-MMP-SH is a bis-cysteine matrix metalloproteinase (MMP)-degradable peptide crosslinker that enables cell-mediated degradation of hyaluronic acid hydrogels. HS-MMP-SH undergoes Michael-type addition with acrylate-functionalized hyaluronic acid to form hydrogels. HA-MMP hydrogels crosslinked by HS-MMP-SH support cell infiltration and vascular invasion in vivo. | |||||||||||||||||||||
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