540770-33-0
540770-33-0
Chemical Structure
Paecilaminol
Synonym(s): FKI-0550
- CAS No.: 540770-33-0
- Formula:C20H43NO
- Molecular Weight:313.56
IUPAC Name: 2-amino-14,16-dimethyloctadecan-3-ol
InChIKey: PRIXJBFEYXJGPF-UHFFFAOYSA-N
SMILES: CC(N)C(O)CCCCCCCCCCC(C)CC(C)CC
Biological Activity: Paecilaminol is an amino alcohol and NADH-fumarate reductase inhibitor (IC50 = 5.1 μM against Ascaris suum) that also inhibits both helminth and mammalian mitochondrial complexes I and III, exhibiting antifungal, antibacterial, nematocidal, insecticidal, and cancer cell growth-inhibitory activities. Paecilaminol can be used in research on helminth infections[1][2][3][4][5].
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Paecilaminol | Paecilaminol is an amino alcohol and NADH-fumarate reductase inhibitor (IC50 = 5.1 μM against Ascaris suum) that also inhibits both helminth and mammalian mitochondrial complexes I and III, exhibiting antifungal, antibacterial, nematocidal, insecticidal, and cancer cell growth-inhibitory activities. Paecilaminol can be used in research on helminth infections. | |||||||||||||||||||||
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References
- [1]. Chen W, et al. Secondary Metabolites of Purpureocilliumlilacinum. Molecules. 2021 Dec 21;27(1):18.
- [2]. Shi XC, et al. Biocontrol mechanisms of Paecilomyces spp. for the management of fungal plant diseases: a review. Pest management science. 2025 Aug;81(8):4200-4219.
- [3]. Ui H, et al. Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550. J Antibiot (Tokyo). 2006 Sep;59(9):591-6. [Content Brief]
- [4]. Masuma, R, et al. Helminth Electron Transport Inhibitors Produced by Fungi. In: Anke, T., Weber, D. (eds) Physiology and Genetics. The Mycota, vol 15. Springer, Berlin, Heidelberg.
- [5]. Ui H, et al. Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550. The Journal of antibiotics. 2006 Sep;59(9):591-6. [Content Brief]
