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Cat. No.: HY-N10184

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Paecilaminol

Name: Paecilaminol
Brand: MedChemExpress
SKU: HY-N10184
Availability: PreOrder

(Synonyms: FKI-0550)

Paecilaminol is an amino alcohol and NADH-fumarate reductase inhibitor (IC₅₀ = 5.1 μM against Ascaris suum) that also inhibits both helminth and mammalian mitochondrial complexes I and III, exhibiting antifungal, antibacterial, nematocidal, insecticidal, and cancer cell growth-inhibitory activities. Paecilaminol can be used in research on helminth infections.

For research use only. We do not sell to patients.

CAS No.: 540770-33-0
Formula: C₂₀H₄₃NO
Molecular Weight:313.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Paecilaminol Chemical Structure

CAS No.: 540770-33-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

All Parasite Isoforms :

In Vitro

Anti-cancerFungal InfectionBacterial InfectionParasitic Infection

Anti-cancer

Paecilaminol inhibits the growth of human cancer cell lines K562, MCF-7, HL-60, and BGC-823 and acts as an NADH-fumarate reductase inhibitor^[1].

Fungal Infection

Paecilaminol (100 μg/mL) exhibits antifungal activity against Aspergillus niger ATCC6275 and Mucor racemosus IFO4581, with an MIC of 100 μg/mL^[2].

Bacterial Infection

Paecilaminol (12.5-25 μg/mL) shows antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, and Mycobacterium smegmatis^[2].
Paecilaminol inhibits Ascaris suum NADH-fumarate reductase with an IC₅₀ of 5.1 μM, and this inhibition is not affected by the presence of 30 mg/mL bovine serum albumin^[5].

Parasitic Infection

Paecilaminol exhibits nematicidal and insecticidal activities, with a minimum inhibitory concentration for growth of 20 μg/mL against C. elegans and 5 μg/mL against A. salina^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 540770-33-0
Molecular Weight 313.56
Formula C₂₀H₄₃NO
SMILES

CC(N)C(O)CCCCCCCCCCC(C)CC(C)CC
Synonyms

FKI-0550
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Microorganisms
Paecilomyces sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen W, et al. Secondary Metabolites of Purpureocilliumlilacinum. Molecules. 2021 Dec 21;27(1):18.

[2]. Shi XC, et al. Biocontrol mechanisms of Paecilomyces spp. for the management of fungal plant diseases: a review. Pest management science. 2025 Aug;81(8):4200-4219.

[3]. Ui H, et al. Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550. J Antibiot (Tokyo). 2006 Sep;59(9):591-6. [Content Brief]

[4]. Masuma, R, et al. Helminth Electron Transport Inhibitors Produced by Fungi. In: Anke, T., Weber, D. (eds) Physiology and Genetics. The Mycota, vol 15. Springer, Berlin, Heidelberg.

[5]. Ui H, et al. Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550. The Journal of antibiotics. 2006 Sep;59(9):591-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Paecilaminol

All Parasite Isoforms

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

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Help & FAQs

Bioz

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Paecilaminol

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Biological Activity

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