57469-82-6
Chemical Structure
Ibuprofen arginine
- CAS No.: 57469-82-6
- Formula:C19H32N4O4
- Molecular Weight:380.48
IUPAC Name: L-arginine compound with 2-(4-isobutylphenyl)propanoic acid (1:1)
InChIKey: GCCOJNYCFNSJII-VWMHFEHESA-N
SMILES: N=C(N)NCCC[C@H](N)C(O)=O.OC(C(C1=CC=C(C=C1)CC(C)C)C)=O
Biological Activity: Ibuprofen arginine is an orally active L-arginine salt of Ibuprofen (HY-78131). Ibuprofen arginine inhibits COX-2-dependent PGE2 production, inhibits iNOS and NOX-2, and reduces pro-inflammatory mediators, nitrite, ROS, oxidative stress, and cytokine secretion. Ibuprofen arginine inhibits ERK1/2 and STAT3 phosphorylation and attenuates M1 polarization. Ibuprofen arginine can serve as a substrate to provide L-arginine to support iNOS-mediated nitrite production and eNOS-mediated NO release, reversing NOS inhibitor-induced dysfunction and L-NAME (HY-18729)-induced contraction. Ibuprofen arginine alleviates joint inflammation and has antibacterial activity. Ibuprofen arginine can be used in research on inflammation-related diseases and pain[1][2][3][4][5].
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Ibuprofen arginine | Ibuprofen arginine is an orally active L-arginine salt of Ibuprofen (HY-78131). Ibuprofen arginine inhibits COX-2-dependent PGE2 production, inhibits iNOS and NOX-2, and reduces pro-inflammatory mediators, nitrite, ROS, oxidative stress, and cytokine secretion. Ibuprofen arginine inhibits ERK1/2 and STAT3 phosphorylation and attenuates M1 polarization. Ibuprofen arginine can serve as a substrate to provide L-arginine to support iNOS-mediated nitrite production and eNOS-mediated NO release, reversing NOS inhibitor-induced dysfunction and L-NAME (HY-18729)-induced contraction. Ibuprofen arginine alleviates joint inflammation and has antibacterial activity. Ibuprofen arginine can be used in research on inflammation-related diseases and pain. | |||||||||||||||||||||
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References
- [1]. Álvarez MS, et al. New formulation of ibuprofen-arginate reduces oxidative stress and prevents macrophage polarization toward M1 phenotype. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2025 Feb;183:117819.
- [2]. Kirkby NS, et al. Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Dec;30(12):4172-4179.
- [3]. Bakshi N, et al. The role of the arginine metabolome in pain: implications for sickle cell disease. Journal of pain research. 2016;9:167-75.
- [4]. Ferrer-Luque CM, et al. Antimicrobial Activity and Cytotoxicity of Nonsteroidal Anti-Inflammatory Drugs against Endodontic Biofilms. Antibiotics (Basel, Switzerland). 2023 Feb 23;12(3):450.
- [5]. Basnet M, et al. Effectiveness of Ibuprofen Arginine, Ibuprofen Lysine, and Indomethacin for Patent Ductus Arteriosus Closure in Neonates. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. 2026 Feb;31(1):37-42.
