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Cat. No.: HY-139068

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Ibuprofen arginine

Ibuprofen arginine is an orally active L-arginine salt of Ibuprofen (HY-78131). Ibuprofen arginine inhibits COX-2-dependent PGE₂ production, inhibits iNOS and NOX-2, and reduces pro-inflammatory mediators, nitrite, ROS, oxidative stress, and cytokine secretion. Ibuprofen arginine inhibits ERK1/2 and STAT3 phosphorylation and attenuates M1 polarization. Ibuprofen arginine can serve as a substrate to provide L-arginine to support iNOS-mediated nitrite production and eNOS-mediated NO release, reversing NOS inhibitor-induced dysfunction and L-NAME (HY-18729)-induced contraction. Ibuprofen arginine alleviates joint inflammation and has antibacterial activity. Ibuprofen arginine can be used in research on inflammation-related diseases and pain.

For research use only. We do not sell to patients.

CAS No.: 57469-82-6
Formula: C₁₉H₃₂N₄O₄
Molecular Weight:380.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Ibuprofen arginine Chemical Structure

CAS No.: 57469-82-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

IL-6

TNF-α

STAT3

iNOS

All NO Synthase Isoforms :

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

All STAT Isoforms :

In Vitro

Innate ImmunityOxidative StressLipid Inflammatory MediatorsCytokines & ChemokinesProtein/Amino Acid MetabolismLocal Vascular RegulationCardiovascular RegulationBacterial InfectionOthers

Innate Immunity

Oxidative Stress

Ibuprofen arginine (Ibu-AR) exerts antioxidant and anti-inflammatory effects in CFBE41o- bronchial epithelial cells and RAW 264.7 macrophages: it scavenges ROS, elevates NO, inhibits nitrite production, downregulates M1-related gene and protein levels such as TNF-α, IL-6, and iNOS, and suppresses p-STAT3/p-ERK1/2 signaling, without altering TLR4 expression^[1].

Innate Immunity

Lipid Inflammatory Mediators

Cytokines & Chemokines

Oxidative Stress

Ibuprofen arginate (24 h) inhibits COX-2-dependent PGE₂ production in RAW264.7 and A549 cells without reducing cell viability^[2].

Innate Immunity

Oxidative Stress

Protein/Amino Acid Metabolism

Ibuprofen arginate (at increasing concentrations based on equimolar L-arginine; 24 h) can provide arginine substrate for iNOS in LPS-stimulated RAW264.7 macrophages cultured in arginine-free medium; it can restore iNOS activity in LPS-stimulated RAW264.7 macrophages in the presence of ADMA, L-NMMA (HY-18732), or L-NAME (HY-18729)^[2].

Local Vascular Regulation

Cardiovascular Regulation

Oxidative Stress

Ibuprofen arginate reverses L-NAME-induced contraction in isolated mouse thoracic aorta; it restores eNOS-dependent vasodilation in isolated rat thoracic aorta^[2].

Bacterial Infection

Ibuprofen arginine (IBP-arginine) (4%; 5 min) is the most effective antibacterial solution against multispecies root canal biofilms, reducing RLU by 96%; it reduces the percentage of viable cells in multispecies endodontic biofilms to 19.84%^[4].

Others

Ibuprofen arginine (4% diluted 1/100) maintains 62.14% and 60.18% 3T3-L1 fibroblast viability at 1 h and 24 h, respectively^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cardiovascular RegulationLocal Vascular Regulation

Cardiovascular Regulation

Local Vascular Regulation

Ibuprofen arginine (57.4 mmol/kg; administered i.v. via the femoral vein; single dose 10 min before L-NAME) prevents L-NAME-induced pressor responses in anesthetized male Wistar Kyoto rats^[2].
Ibuprofen arginine (114.8 mmol/kg; administered i.v. via the femoral vein; given as a single dose after the L-NAME pressor response is established) reverses the established L-NAME-induced pressor response in anesthetized male Wistar Kyoto rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 57469-82-6
Molecular Weight 380.48
Formula C₁₉H₃₂N₄O₄
SMILES

N=C(N)NCCC[C@H](N)C(O)=O.OC(C(C1=CC=C(C=C1)CC(C)C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Álvarez MS, et al. New formulation of ibuprofen-arginate reduces oxidative stress and prevents macrophage polarization toward M1 phenotype. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2025 Feb;183:117819.

[2]. Kirkby NS, et al. Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Dec;30(12):4172-4179.

[3]. Bakshi N, et al. The role of the arginine metabolome in pain: implications for sickle cell disease. Journal of pain research. 2016;9:167-75.

[4]. Ferrer-Luque CM, et al. Antimicrobial Activity and Cytotoxicity of Nonsteroidal Anti-Inflammatory Drugs against Endodontic Biofilms. Antibiotics (Basel, Switzerland). 2023 Feb 23;12(3):450.

[5]. Basnet M, et al. Effectiveness of Ibuprofen Arginine, Ibuprofen Lysine, and Indomethacin for Patent Ductus Arteriosus Closure in Neonates. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. 2026 Feb;31(1):37-42.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Purity & Documentation
References

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Ibuprofen arginine

All NO Synthase Isoforms

All TNF Receptor Isoforms

All Interleukin Related Isoforms

All STAT Isoforms