59163-53-0
59163-53-0
Chemical Structure
Aloenin aglycone
- CAS No.: 59163-53-0
- Formula:C13H12O5
- Molecular Weight:248.23
InChIKey: GJWNAMOGOKAELX-UHFFFAOYSA-N
SMILES: O=C1OC(C2=C(C)C=C(O)C=C2O)=CC(OC)=C1
Biological Activity: Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα[1].
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Aloenin aglycone | Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα. | |||||||||||||||||||||
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