592544-81-5
Chemical Structure
KYS-1
- CAS No.: 592544-81-5
- Formula:C61H82N16O18
- Molecular Weight:1327.40
InChIKey: NSIRVLHIYQWTDO-BRHSRUOZSA-N
SMILES: O=C([C@@H](NC(CNC(CC(C1=CC=C(C=C1O2)OC)=CC2=O)=O)=O)CO)N3[C@H](C(N[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](CCCNC(N)=N)C(N)=O)=O)CCCCNC5=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C5)=O)C)=O)CC(C)C)=O)=O)C)=O)CCC3
Biological Activity: KYS-1 is a specific fluorescent substrate for Cathepsin E, with a Km of 1.90 μM. KYS-1 is specifically cleaved by Cathepsin E at the Phe-Leu bond under acidic conditions (optimal pH approximately 4.0), relieving fluorescence quenching and releasing a strong signal, thereby enabling measurement of Cathepsin E enzyme activity. KYS-1 can be used for breast cancer research[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KYS-1 | 99.34% | KYS-1 is a specific fluorescent substrate for Cathepsin E, with a Km of 1.90 μM. KYS-1 is specifically cleaved by Cathepsin E at the Phe-Leu bond under acidic conditions (optimal pH approximately 4.0), relieving fluorescence quenching and releasing a strong signal, thereby enabling measurement of Cathepsin E enzyme activity. KYS-1 can be used for breast cancer research. | ||||||||||||||||||||
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References
- [1]. Yasuda Y, et al. A new selective substrate for cathepsin E based on the cleavage site sequence of alpha2-macroglobulin. Biological chemistry. 2005 Mar;386(3):299-305. [Content Brief]
- [2]. Kawakubo T, et al. Repression of cathepsin E expression increases the risk of mammary carcinogenesis and links to poor prognosis in breast cancer. Carcinogenesis. 2014 Mar;35(3):714-26.
- [3]. Božič J, et al. Glucosamine prevents polarization of cytotoxic granules in NK-92 cells by disturbing FOXO1/ERK/paxillin phosphorylation. PloS one. 2018;13(7):e0200757.
- [4]. Harada Y, et al. Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis. Pain. 2019 Sep;160(9):2050-2062.
- [5]. Goto S, et al. Role of cathepsin E in decidual macrophage of patients with recurrent miscarriage. Molecular human reproduction. 2014 May;20(5):454-62.
- [6]. Kitamura K, et al. Development of systemic in vitro evolution and its application to generation of peptide-aptamer-based inhibitors of cathepsin E. Journal of molecular biology. 2009 Apr 17;387(5):1186-98.
- [7]. Kawakubo T, et al. Gene expression profiling of mammary glands of cathepsin E-deficient mice compared with wild-type littermates. Biochimie. 2008 Feb;90(2):396-404.
