6286-09-5
Chemical Structure
NSC10010 hydrochloride
- CAS No.: 6286-09-5
- Formula:C31H42Cl2N4O2
- Molecular Weight:573.60
IUPAC Name: N1,N9-bis(6-methoxy-2-methylquinolin-4-yl)nonane-1,9-diamine dihydrochloride
InChIKey: PYXMJTIQBGOWBI-UHFFFAOYSA-N
SMILES: CC1=NC2=CC=C(OC)C=C2C(NCCCCCCCCCNC3=CC(C)=NC4=CC=C(OC)C=C34)=C1.[H]Cl.[H]Cl
Biological Activity: NSC10010 hydrochloride is a Mycobacterium tuberculosis ClpC1 inhibitor and differentiation inducer (IC50 = 4 µM; Kd = 2.8 µM). NSC10010 hydrochloride inhibits the ATPase and proteolytic activities of ClpC1 by binding to it, and downregulates E2F1, induces DNA damage, apoptosis, and lipid droplet accumulation, thereby inhibiting breast cancer cell proliferation and Mycobacterium tuberculosis H37Rv growth. NSC10010 hydrochloride can be used for research on breast cancer and tuberculosis[1][2].
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NSC10010 hydrochloride | NSC10010 hydrochloride is a Mycobacterium tuberculosis ClpC1 inhibitor and differentiation inducer (IC50 = 4 µM; Kd = 2.8 µM). NSC10010 hydrochloride inhibits the ATPase and proteolytic activities of ClpC1 by binding to it, and downregulates E2F1, induces DNA damage, apoptosis, and lipid droplet accumulation, thereby inhibiting breast cancer cell proliferation and Mycobacterium tuberculosis H37Rv growth. NSC10010 hydrochloride can be used for research on breast cancer and tuberculosis. | |||||||||||||||||||||
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References
- [1]. Martirosyan AR, et al. Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model. Biochemical pharmacology. 2004 Nov 01;68(9):1729-38.
- [2]. Bhanot A, et al. Discovery of small molecule inhibitors of Mycobacterium tuberculosis ClpC1: SAR studies and antimycobacterial evaluation. Results in Chemistry. 2023 Jan 1;5:100904.
