64280-22-4
Chemical Structure
Ovalitenone
- CAS No.: 64280-22-4
- Formula:C19H14O6
- Molecular Weight:338.31
InChIKey: SDJBCBKWKASUCJ-UHFFFAOYSA-N
SMILES: O=C(CC(C1=CC=C2OC=CC2=C1OC)=O)C3=CC=C4OCOC4=C3
Biological Activity: Ovalitenone is a flavonoid found in the plant Millettia peguensis and acts as a CYP1A1/CYP1B1 inhibitor with IC50 values of 0.28 and 0.6 μM, respectively. Ovalitenone significantly decreases the levels of N-cadherin, snail, and slug while increasing E-cadherin, thereby inhibiting the EMT pathway. Ovalitenone also inhibits the regulatory signaling pathways of focal adhesion kinase (FAK), ATP-dependent tyrosine kinase (AKT), mammalian target of rapamycin (mTOR), and cell division cycle 42 (Cdc42). Ovalitenone inhibits the proliferation, migration, invasion, epithelial-mesenchymal transition, and cancer stem cell-like phenotype of lung cancer cells. Ovalitenone can be used in lung cancer-related research[1][2][3][4].
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Ovalitenone | Ovalitenone is a flavonoid found in the plant Millettia peguensis and acts as a CYP1A1/CYP1B1 inhibitor with IC50 values of 0.28 and 0.6 μM, respectively. Ovalitenone significantly decreases the levels of N-cadherin, snail, and slug while increasing E-cadherin, thereby inhibiting the EMT pathway. Ovalitenone also inhibits the regulatory signaling pathways of focal adhesion kinase (FAK), ATP-dependent tyrosine kinase (AKT), mammalian target of rapamycin (mTOR), and cell division cycle 42 (Cdc42). Ovalitenone inhibits the proliferation, migration, invasion, epithelial-mesenchymal transition, and cancer stem cell-like phenotype of lung cancer cells. Ovalitenone can be used in lung cancer-related research. | |||||||||||||||||||||
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References
- [1]. Sanookpan K, et al. Ovalitenone Inhibits the Migration of Lung Cancer Cells via the Suppression of AKT/mTOR and Epithelial-to-Mesenchymal Transition. Molecules (Basel, Switzerland). 2021 Jan 26;26(3):638. [Content Brief]
- [2]. Sharma R, et al. Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells. Bioorganic & medicinal chemistry. 2018 Dec 15;26(23-24):6076-6086. [Content Brief]
- [3]. Tungsukruthai S, et al. Cycloartocarpin Inhibits Migration through the Suppression of Epithelial-to-Mesenchymal Transition and FAK/AKT Signaling in Non-Small-Cell Lung Cancer Cells. Molecules (Basel, Switzerland). 2022 Nov 22;27(23):8121.
- [4]. Sung CJ, et al. Fucoidan from Sargassum hemiphyllum inhibits the stemness of cancer stem cells and epithelial-mesenchymal transitions in bladder cancer cells. International journal of biological macromolecules. 2022 Nov 30;221:623-633. [Content Brief]
