67172-84-3
Chemical Structure
Kuwanon D
- CAS No.: 67172-84-3
- Formula:C25H26O6
- Molecular Weight:422.47
InChIKey: IJVOVAHXZFALHZ-UHFFFAOYSA-N
SMILES: O=C1C2=C(OC(C1)C3=C(O)C=C(OC4(CCC5C4C6C5(C)C)C)C6=C3)C=C(O)C=C2O
Biological Activity: Kuwanon D is a prenylated flavanone found in the root bark of Morus alba L. Kuwanon D is predicted to be a high-affinity binder of SARS-CoV-2 main protease (Mpro), with favorable bioavailability and compliance with Lipinski's Rule of Five. Kuwanon D is an active component of Morus alba root bark identified as a lung cancer-related gene-targeting compound through network pharmacology screening. Kuwanon D is applicable to research related to COVID-19 and lung cancer[1][2][3].
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Kuwanon D | Kuwanon D is a prenylated flavanone found in the root bark of Morus alba L. Kuwanon D is predicted to be a high-affinity binder of SARS-CoV-2 main protease (Mpro), with favorable bioavailability and compliance with Lipinski's Rule of Five. Kuwanon D is an active component of Morus alba root bark identified as a lung cancer-related gene-targeting compound through network pharmacology screening. Kuwanon D is applicable to research related to COVID-19 and lung cancer. | |||||||||||||||||||||
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References
- [1]. Nomura T, et al. Constituents of cultivated mulberry tree. Planta medica. 1983 Mar;47(3):151-6. [Content Brief]
- [2]. ao Y, et al. Computational assessment of herbal medicine-derived compounds as potential inhibitors of SARS-CoV-2 main protease. J Biomol Struct Dyn. 2023 Nov;41(19):9602-9613.
- [3]. Shao YY, et al. Molecular targets and mechanisms of cortex mori for lung cancer treatment: a network pharmacology study, molecular docking and and experimental validation. Frontiers in oncology. 2025;15:1587856.
