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Cat. No.: HY-N21559

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Kuwanon D

Kuwanon D is a prenylated flavanone found in the root bark of Morus alba L. Kuwanon D is predicted to be a high-affinity binder of SARS-CoV-2 main protease (Mpro), with favorable bioavailability and compliance with Lipinski's Rule of Five. Kuwanon D is an active component of Morus alba root bark identified as a lung cancer-related gene-targeting compound through network pharmacology screening. Kuwanon D is applicable to research related to COVID-19 and lung cancer.

For research use only. We do not sell to patients.

CAS No.: 67172-84-3
Formula: C₂₅H₂₆O₆
Molecular Weight:422.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kuwanon D Chemical Structure

CAS No.: 67172-84-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Viral InfectionAnti-cancerOthers

Viral Infection

Kuwanon D exhibits strong binding affinity for SARS-CoV-2 Mpro in molecular docking, with a binding energy of -8.9 kcal/mol, and forms a hydrogen bond with Gly-143^[2].
Kuwanon D (100 ns)\nDuring MD simulations, the complex structure of Kuwanon D and SARS-CoV-2 M^pro remains stable, with an average backbone RMSD of 1.43 Å and an average RoG of 21.71 Å^[2].
Kuwanon D (70-100 ns) binds spontaneously to SARS-CoV-2 M^pro. The binding free energy calculated by MM-PBSA is -24.16 kcal/mol. The binding interaction is mainly driven by van der Waals interactions, and Met-49 and Met-165 are key contributing residues^[2].

Anti-cancer

Kuwanon D is one of the key active components of Cortex Mori. In a drug-disease interaction network comprising 163 targets, it acts on multiple lung cancer-related genes^[3].

Others

Kuwanon D reacts with a ferric chloride methanol solution to produce a deep purplish-red color. It yields positive results in the magnesium-hydrochloric acid test and sodium borohydride test, but a negative result in the zinc-hydrochloric acid test^[1].
Kuwanon D is a drug-like compound that satisfies all of Lipinski's rules, with a bioavailability score of 0.55^[2].
Kuwanon D is an active component of Cortex Mori, with an oral bioavailability of 31.09% and a drug-likeness score of 0.80, which meet the preset screening thresholds^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Protocol for Pharmacokinetic Study

Chemical Information

CAS No. 67172-84-3
Molecular Weight 422.47
Formula C₂₅H₂₆O₆
SMILES

O=C1C2=C(OC(C1)C3=C(O)C=C(OC4(CCC5C4C6C5(C)C)C)C6=C3)C=C(O)C=C2O
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nomura T, et al. Constituents of cultivated mulberry tree. Planta medica. 1983 Mar;47(3):151-6. [Content Brief]

[2]. ao Y, et al. Computational assessment of herbal medicine-derived compounds as potential inhibitors of SARS-CoV-2 main protease. J Biomol Struct Dyn. 2023 Nov;41(19):9602-9613.

[3]. Shao YY, et al. Molecular targets and mechanisms of cortex mori for lung cancer treatment: a network pharmacology study, molecular docking and and experimental validation. Frontiers in oncology. 2025;15:1587856.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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