6741-73-7
6741-73-7
Chemical Structure
4′-Thiouridine
Synonym(s): 1-(4-Thio-beta-D-ribofuranosyl)uracil
- CAS No.: 6741-73-7
- Formula:C9H12N2O5S
- Molecular Weight:260.27
IUPAC Name: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl)pyrimidine-2,4(1H,3H)-dione
InChIKey: MUSPKJVFRAYWAR-XVFCMESISA-N
SMILES: O=C(N([C@@H]1S[C@H](CO)[C@@H](O)[C@H]1O)C=C2)NC2=O
Biological Activity: 4′-Thiouridine (1-(4-Thio-beta-D-ribofuranosyl)uracil) is a thio analog of thymidine. 4′-Thiouridine can be used to synthesize 4'-thionucleosides with antiviral and anticancer activities. 4′-Thiouridine can be used for RNA-sequencing[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4′-Thiouridine | 98.68% | 4′-Thiouridine (1-(4-Thio-beta-D-ribofuranosyl)uracil) is a thio analog of thymidine. 4′-Thiouridine can be used to synthesize 4'-thionucleosides with antiviral and anticancer activities. 4′-Thiouridine can be used for RNA-sequencing. | ||||||||||||||||||||
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References
- [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]
- [2]. Benckendorff CMM, et al., Preparation of a 4'-Thiouridine Building-Block for Solid-Phase Oligonucleotide Synthesis. Curr Protoc. 2023 Sep;3(9):e878. [Content Brief]
- [3]. Garibaldi A, et al., Isolation of Newly Transcribed RNA Using the Metabolic Label 4-Thiouridine. Methods Mol Biol. 2017;1648:169-176. [Content Brief]
