70375-43-8
70375-43-8
Chemical Structure
SCH-202676
- CAS No.: 70375-43-8
- Formula:C15H13N3S
- Molecular Weight:267.35
IUPAC Name: (Z)-N-methyl-2,3-diphenyl-1,2,4-thiadiazol-5(2H)-imine
InChIKey: FFUBTEITUNMMOK-NXVVXOECSA-N
SMILES: C/N=C1N=C(C2=CC=CC=C2)N(C3=CC=CC=C3)S/1
Biological Activity: SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM[1][2][3][4].
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SCH-202676 | 99.46% | SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM. | ||||||||||||||||||||
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References
- [1]. Ren P, et al. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Eur J Med Chem. 2023 Jan 18;249:115129. [Content Brief]
- [2]. Lewandowicz AM, et al. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br J Pharmacol. 2006 Feb;147(4):422-9. [Content Brief]
- [3]. Fawzi A B, et al. SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors[J]. Molecular Pharmacology, 2001, 59(1): 30-37.
- [4]. Gao ZG, et al. Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 2004 May 7;74(25):3173-80. [Content Brief]
