709611-59-6
Chemical Structure
Melimine
- CAS No.: 709611-59-6
- Formula:C158H290N74O35
- Molecular Weight:3786.47
SMILES: O=C([C@@H](N)[C@@H](C)O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CO)=O)C(C)C)=O)CCCNC(N)=N)=O)CCC1)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCCN)=O)CC(N)=O)=O)CCCCN)=O)[C@H](CC)C)=O)CC2=CNC3=CC=CC=C23)=O)CO)=O)[C@H](CC)C)=O)CC(C)C
Biological Activity: Melimine is an antimicrobial peptide with broad-spectrum antimicrobial activity against Gram-negative/Gram-positive bacteria, fungi and protozoa. Melimine neutralizes endotoxin activity by interacting with the phosphate groups of lipid A, depolarizes and permeabilizes the cytoplasmic membrane of *Pseudomonas aeruginosa*, and induces bacterial lysis. Melimine exerts additive antiviral effects against H1N1 and MHV-1 when used in combination with RK610. Melimine retains its antimicrobial activity when conjugated to polymer and titanium surfaces. Melimine can be used in infection-related research[1][2][3].
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Melimine | Melimine is an antimicrobial peptide with broad-spectrum antimicrobial activity against Gram-negative/Gram-positive bacteria, fungi and protozoa. Melimine neutralizes endotoxin activity by interacting with the phosphate groups of lipid A, depolarizes and permeabilizes the cytoplasmic membrane of *Pseudomonas aeruginosa*, and induces bacterial lysis. Melimine exerts additive antiviral effects against H1N1 and MHV-1 when used in combination with RK610. Melimine retains its antimicrobial activity when conjugated to polymer and titanium surfaces. Melimine can be used in infection-related research. | |||||||||||||||||||||
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References
- [1]. Urmi UL, et al. Synergistic effects of peptide mimics against enveloped viruses. Virology. 2025 Sep;610:110599.
- [2]. Salvagni E, et al. Short and ultrashort antimicrobial peptides anchored onto soft commercial contact lenses inhibit bacterial adhesion. Colloids and surfaces. B, Biointerfaces. 2020 Dec;196:111283.
- [3]. Yasir M, et al. Comparative mode of action of the antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa. Scientific reports. 2019 May 08;9(1):7063. [Content Brief]
