7423-96-3
Chemical Structure
3-Fluoro-L-tyrosine
- CAS No.: 7423-96-3
- Formula:C9H10FNO3
- Molecular Weight:199.18
IUPAC Name: (S)-2-amino-3-(3-fluoro-4-hydroxyphenyl)propanoic acid
InChIKey: VIIAUOZUUGXERI-ZETCQYMHSA-N
SMILES: C1=CC(=C(C=C1C[C@@H](C(=O)O)N)F)O
Biological Activity: 3-Fluoro-L-tyrosine is a tyrosine analog that inhibits the transamination of tyrosine transaminase (TAT). 3-Fluoro-L-tyrosine can be biologically incorporated into proteins in place of tyrosine. 3-Fluoro-L-tyrosine can mimic the substrate of rat liver tyrosine transaminase, markedly disrupting the tyrosine-TAT association. 3-Fluoro-L-tyrosine is useful for research related to tumors and tyrosine metabolism disorders[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3-Fluoro-L-tyrosine | 99.89% | 3-Fluoro-L-tyrosine is a tyrosine analog that inhibits the transamination of tyrosine transaminase (TAT). 3-Fluoro-L-tyrosine can be biologically incorporated into proteins in place of tyrosine. 3-Fluoro-L-tyrosine can mimic the substrate of rat liver tyrosine transaminase, markedly disrupting the tyrosine-TAT association. 3-Fluoro-L-tyrosine is useful for research related to tumors and tyrosine metabolism disorders. | ||||||||||||||||||||
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References
- [1]. Iron A, et al. Action of the phosphonic analogue of tyrosine and of other tyrosine derivatives on rat liver tyrosine aminotransferase. Amino acids. 1993 Feb;5(1):33-7. [Content Brief]
- [2]. Wong MC, et al. Global incorporation of meta-fluorotyrosine or meta-fluorophenylalanine into 1, 2-catechol dioxygenase modulates the binding affinities of substrates. Frontiers in Synthetic Biology. 2024 Aug 2;2:1419557.
- [3]. Hitotsuyanagi Y, et al. Synthesis and cytotoxicity evaluation of tyrosine-3 or tyrosine-6 fluorinated analogues of RA-VII, an antitumor bicyclic hexapeptide from Rubia cordifolia. Phytochemistry Letters. 2025 Jun 1;67:102967.
- [4]. Blanchard DL. Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics. Oregon State University; 2008.
- [5]. O'Connor NK, et al. Novel fluorinated lipopeptides from Bacillus sp. CS93 via precursor-directed biosynthesis. Amino acids. 2014 Dec;46(12):2745-52.
