75057-96-4
Chemical Structure
Novclobiocin 101
- CAS No.: 75057-96-4
- Formula:C35H38N2O11
- Molecular Weight:662.68
InChIKey: GMMYCBAAMDJSHV-YQQRZDPSSA-N
SMILES: OC(C1=CC=C(O[C@H]2[C@@H]([C@@H]([C@H](C(C)(O2)C)OC)OC(C3=CC=C(C)N3)=O)O)C=C1O4)=C(NC(C5=CC(C/C=C(C)\C)=C(C=C5)O)=O)C4=O
Biological Activity: Novclobiocin 101 is a non-halogenated chloro Novobiocin (HY-B0425) analog and a DNA gyrase inhibitor (IC50 0.9 μM) that also inhibits DNA topoisomerase IV (IC50 6 μM). Novclobiocin 101 inhibits gyrase-catalyzed DNA supercoiling and topoisomerase IV-mediated DNA decatenation. Novclobiocin 101 exhibits antibacterial activity against Bacillus subtilis and shows cytotoxicity against small cell lung cancer cells. Novclobiocin 101 can be used for research on bacterial and fungal infections as well as cancer[1][2].
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Novclobiocin 101 | Novclobiocin 101 is a non-halogenated chloro Novobiocin (HY-B0425) analog and a DNA gyrase inhibitor (IC50 0.9 μM) that also inhibits DNA topoisomerase IV (IC50 6 μM). Novclobiocin 101 inhibits gyrase-catalyzed DNA supercoiling and topoisomerase IV-mediated DNA decatenation. Novclobiocin 101 exhibits antibacterial activity against Bacillus subtilis and shows cytotoxicity against small cell lung cancer cells. Novclobiocin 101 can be used for research on bacterial and fungal infections as well as cancer. | |||||||||||||||||||||
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References
- [1]. Flatman RH, et al. Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis. Antimicrob Agents Chemother. 2006 Apr;50(4):1136-42.
- [2]. Dramae A, et al. Antimalarial 20-membered macrolides from Streptomyces sp. BCC33756. Tetrahedron. 2013 Sep 23;69(38):8205-8.
